Rabbit Anti-AKR1B1 Polyclonal Antibody – Cat# MBS840770

AKR1B1 Antibody – Rabbit Polyclonal

Name: AKR1B1 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS840770
Price: 375 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS840770

Polyclonal Antibody to detect AKR1B1 in human samplesBackground: Aldose reductase (also designated AKR1B1, ALDR1, ALR2 or AR) is member of the monomeric NADPH-dependent aldoketoreductase family. Aldose reductase, which has a molecular mass of 36 kDa,… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

AKR1B1, Polyclonal Antibody

Full Product Name

AKR1B1 Antibody (Center)

Product Gene Name

anti-AKR1B1 antibody

Product Synonym Names

AKR1B1; ALDR1; Aldose reductase; Aldehyde reductase; Aldo-keto reductase family 1 member B1.

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

100 ul of antibody in PBS with 0.09% (W/V) sodium azide
Appearance: Colorless liquid

Purity/Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Preparation and Storage

At -20 degree C
Shelf Life: 12 months

Molecular Weight

35,853 Da

OMIM

103880

3D Structure

ModBase 3D Structure for P15121

Immunogen

This AKR1B1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 102-135 amino acids from the Central region of human AKR1B1.

Positive Control

Western blot: Jurkat and 293 cell lysates, IHC: human colon carcinoma, IF: 293 cells.

Handling

The antibody solution should be gently mixed before use.

Product Categories/Family for anti-AKR1B1 antibody

Antibodies & Supporting Tools; Antibodies for Metabolic Processes (NEW) Diabetes; Obesity & Metabolic Syndrome; Antibodies (NEW) Antibodies & Supporting Tools; Primary Antibodies (A-Z)

Applications Tested/Suitable for anti-AKR1B1 antibody

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Application Notes for anti-AKR1B1 antibody

Western blot: ~1:1000, IHC: ~1:10 - 1:50, IF: ~1:10 - 1:50.

Other Notes

Small volumes of anti-AKR1B1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for AKR1B1 purchase

MBS840770 is an antibody targeting AKR1B1. Also known as AKR1B1 Antibody (Center). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for AKR1B1. It may not necessarily be applicable to this product.

NCBI GI #

4502049

NCBI GeneID

231

NCBI Accession #

NP_001619.1

UniProt Primary Accession #

P15121

UniProt Secondary Accession #

Q5U031; Q6FGA4; Q6ICP2; Q9BS21; Q9UCI9; B2R8N3

UniProt Related Accession #

P15121

GenBank Nucleotide #

NM_001628.2

NCBI Official Full Name

aldose reductase

NCBI Official Synonym Full Names

aldo-keto reductase family 1, member B1 (aldose reductase)

NCBI Official Symbol

AKR1B1

NCBI Official Synonym Symbols

AR; ADR; ALR2; ALDR1

UniProt Protein Name

Aldose reductase

UniProt Synonym Protein Names

Aldehyde reductase; Aldo-keto reductase family 1 member B1

Protein Family

Aldose reductase

UniProt Gene Name

AKR1B1

UniProt Synonym Gene Names

ALDR1; AR

UniProt Entry Name

ALDR_HUMAN

NCBI Protein Information

aldose reductase

NCBI Summary for AKR1B1

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. Multiple pseudogenes have been identified for this gene. The nomenclature system used by the HUGO Gene Nomenclature Committee to define human aldo-keto reductase family members is known to differ from that used by the Mouse Genome Informatics database. [provided by RefSeq, Feb 2009]

UniProt Comments for AKR1B1

AKR1B1: Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies. Belongs to the aldo/keto reductase family.

Protein type: Carbohydrate Metabolism - fructose and mannose; Lipid Metabolism - glycerolipid; Carbohydrate Metabolism - galactose; Oxidoreductase; Carbohydrate Metabolism - pyruvate; Carbohydrate Metabolism - pentose and glucuronate interconversions; EC 1.1.1.21

Chromosomal Location of Human Ortholog: 7q35

Cellular Component: nucleoplasm; extracellular space; cytoplasm; cytosol

Molecular Function: glyceraldehyde oxidoreductase activity; electron carrier activity; aldo-keto reductase activity; aldehyde reductase activity

Biological Process: steroid metabolic process; carbohydrate metabolic process; response to stress; C21-steroid hormone biosynthetic process

Research Articles on AKR1B1

1. Higher expression of PLA2G2A, PTGS2, AKR1B1, AKR1C3 and ABCC4 was seen in 22-B endometriosis cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-AKR1B1 antibody

Disease Name	Pubmed Publications
Diabetes Complications Antibodies	>39 publications with AKR1B1 and Diabetes Complications
Inflammation Antibodies	>14 publications with AKR1B1 and Inflammation
Cataract Antibodies	>10 publications with AKR1B1 and Cataract
Hyperglycemia Antibodies	>9 publications with AKR1B1 and Hyperglycemia
Kidney Diseases Antibodies	>8 publications with AKR1B1 and Kidney Diseases
Necrosis Antibodies	>7 publications with AKR1B1 and Necrosis
Nervous System Diseases Antibodies	>6 publications with AKR1B1 and Nervous System Diseases
Breast Neoplasms Antibodies	>6 publications with AKR1B1 and Breast Neoplasms
Pain Antibodies	>3 publications with AKR1B1 and Pain
Adenocarcinoma Antibodies	>3 publications with AKR1B1 and Adenocarcinoma

Organs/Tissues associated with anti-AKR1B1 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>22 publications with AKR1B1 and Blood
Uterus Antibodies	>15 publications with AKR1B1 and Uterus
Eye Antibodies	>14 publications with AKR1B1 and Eye
Liver Antibodies	>12 publications with AKR1B1 and Liver
Lung Antibodies	>11 publications with AKR1B1 and Lung
Kidney Antibodies	>9 publications with AKR1B1 and Kidney
Muscle Antibodies	>8 publications with AKR1B1 and Muscle
Placenta Antibodies	>7 publications with AKR1B1 and Placenta
Vascular Antibodies	>7 publications with AKR1B1 and Vascular
Heart Antibodies	>7 publications with AKR1B1 and Heart