Rabbit Anti-PFN1 Polyclonal Antibody – Cat# MBS840785

Profilin-1 (PFN1) Antibody – Rabbit Polyclonal

Name: PFN1 Antibody; Polyclonal; Rabbit; MyBioSource
Brand: MyBioSource
SKU: MBS840785
Price: 215 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS840785

Background: Profilin is a protein which maintains and shapes cytoskeleton by binding to actin. Profilin 1 has function in breast cancer cell motility, radial migration and glial cell adhesion. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

Profilin-1 (Pfn1), Polyclonal Antibody

Full Product Name

Profilin-1 Antibody

Product Gene Name

anti-Pfn1 antibody

Product Synonym Names

Profilin I; Pfn1; Epididymis tissue protein Li 184a

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human, Mouse, Rat, Bovine

Form/Format

100 ug (0.5 mg/ml) affinity purified rabbit anti-Profilin-1 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 5 mM EDTA and 0.01% thimerosal.
Appearance: Colorless liquid

Purity/Purification

Affinity purified

Concentration

0.5 mg/ml (lot specific)

Preparation and Storage

At -20 degree C
Shelf Life: 12 months

Molecular Weight

14,957 Da

3D Structure

ModBase 3D Structure for P62963

Immunogen

Synthetic peptide close to C-terminus of rat Profilin-1

Positive Control

Jurkat cell lysate, 3T3 cell lysate, rat kidney tissue lysate

Handling

The antibody solution should be gently mixed before use.

Product Categories/Family for anti-Pfn1 antibody

Antibodies & Supporting Tools; Primary Antibodies (A-Z) Signal Transduction; Signal Transduction Antibodies (A-Z)

Applications Tested/Suitable for anti-Pfn1 antibody

Western Blot (WB)

Application Notes for anti-Pfn1 antibody

The antibody can be used in Western Blot analysis (1-4 ug/ml). However, the optimal concentrations should be determined individually. Blocking peptide is available separately. Expected band is ~15 kDa.

Other Notes

Small volumes of anti-Pfn1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Pfn1 purchase

MBS840785 is an antibody targeting Pfn1. Also known as Profilin-1 Antibody. Reactive in Human, Mouse, Rat, Bovine. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for Pfn1. It may not necessarily be applicable to this product.

NCBI GI #

42476144

NCBI GeneID

64303

NCBI Accession #

NP_071956.2

UniProt Primary Accession #

P62963

UniProt Secondary Accession #

P10924

UniProt Related Accession #

P62963

GenBank Nucleotide #

NM_022511.2

NCBI Official Full Name

profilin-1

NCBI Official Synonym Full Names

profilin 1

NCBI Official Symbol

Pfn1

UniProt Protein Name

Profilin-1

UniProt Synonym Protein Names

Profilin I

Protein Family

Profilin

UniProt Gene Name

Pfn1

UniProt Entry Name

PROF1_RAT

NCBI Protein Information

profilin-1

NCBI Summary for Pfn1

regulates actin polymerization; may reorganize the actin cytoskeleton; may be involved in the pathogenesis of glomerulonephritis [RGD, Feb 2006]

UniProt Comments for Pfn1

profilin 1: a ubiquitous actin monomer-binding protein belonging to the profilin family. At high concentrations, profilin 1 prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Deletion of this gene is associated with Miller-Dieker syndrome.

Protein type: Cytoskeletal; Actin-binding; Motility/polarity/chemotaxis

Cellular Component: neuron projection; focal adhesion; cytoskeleton; membrane; cytoplasm; synapse; nucleus

Molecular Function: protein binding; phosphatidylinositol-4,5-bisphosphate binding; Rho GTPase binding; adenyl-nucleotide exchange factor activity; actin binding; receptor binding

Biological Process: regulation of transcription from RNA polymerase II promoter; response to organic substance; positive regulation of DNA metabolic process; negative regulation of actin filament bundle formation; negative regulation of stress fiber formation; positive regulation of actin filament polymerization; positive regulation of viral transcription; positive regulation of ATPase activity; negative regulation of actin filament polymerization; actin polymerization and/or depolymerization; neural tube closure; positive regulation of stress fiber formation; positive regulation of transcription from RNA polymerase II promoter

Research Articles on Pfn1

1. role in morphological plasticity of peripheral astrocytic processes

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-Pfn1 antibody

Reference Product	PubMed Publications
Diap1 antibody	>6 publications with Pfn1 and Diap1
Actr3 antibody	>5 publications with Pfn1 and Actr3
Cap1 antibody	>2 publications with Pfn1 and Cap1
Apbb1ip antibody	>1 publications with Pfn1 and Apbb1ip
Daam1 antibody	>1 publications with Pfn1 and Daam1

Pathways associated with anti-Pfn1 antibody

Products by Pathway	Pathway Diagram
Axon Guidance Pathway antibodies	Axon Guidance Pathway Diagram
Developmental Biology Pathway antibodies	Developmental Biology Pathway Diagram
G13 Signaling Pathway antibodies	G13 Signaling Pathway Diagram
Hemostasis Pathway antibodies	Hemostasis Pathway Diagram
PCP/CE Pathway antibodies	PCP/CE Pathway Diagram
Platelet Activation, Signaling And Aggregation Pathway antibodies	Platelet Activation, Signaling And Aggregation Pathway Diagram
Platelet Degranulation Pathway antibodies	Platelet Degranulation Pathway Diagram
RHO GTPase Effectors Pathway antibodies	RHO GTPase Effectors Pathway Diagram
RHO GTPases Activate Formins Pathway antibodies	RHO GTPases Activate Formins Pathway Diagram
Rap1 Signaling Pathway antibodies	Rap1 Signaling Pathway Diagram

Diseases associated with anti-Pfn1 antibody

Disease Name	Pubmed Publications
Breast Neoplasms Antibodies	>19 publications with Pfn1 and Breast Neoplasms
Adenocarcinoma Antibodies	>12 publications with Pfn1 and Adenocarcinoma
Brain Diseases Antibodies	>11 publications with Pfn1 and Brain Diseases
Inflammation Antibodies	>7 publications with Pfn1 and Inflammation
Kidney Diseases Antibodies	>6 publications with Pfn1 and Kidney Diseases
Liver Neoplasms Antibodies	>6 publications with Pfn1 and Liver Neoplasms
Liver Diseases Antibodies	>6 publications with Pfn1 and Liver Diseases
Carcinoma, Hepatocellular Antibodies	>4 publications with Pfn1 and Carcinoma, Hepatocellular
Hypertension Antibodies	>3 publications with Pfn1 and Hypertension
Hypertrophy Antibodies	>2 publications with Pfn1 and Hypertrophy

Organs/Tissues associated with anti-Pfn1 antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>36 publications with Pfn1 and Brain
Muscle Antibodies	>24 publications with Pfn1 and Muscle
Kidney Antibodies	>13 publications with Pfn1 and Kidney
Embryonic Tissue Antibodies	>11 publications with Pfn1 and Embryonic Tissue
Liver Antibodies	>9 publications with Pfn1 and Liver
Artery Antibodies	>7 publications with Pfn1 and Artery
Testis Antibodies	>6 publications with Pfn1 and Testis
Spleen Antibodies	>6 publications with Pfn1 and Spleen
Thymus Antibodies	>5 publications with Pfn1 and Thymus
Lung Antibodies	>3 publications with Pfn1 and Lung