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BID Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS840806

Background: Bid, a BH3 domain-containing proapoptotic Bcl-2 family member, is localized in the cytosolic fraction of cells as an inactive precursor. Its active form is generated upon proteolytic cleavage by caspase-8 in the Fas signaling pathway. Cleaved Bid… More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
Bid, Polyclonal Antibody
Full Product Name
Bid Antibody
Product Gene Name
anti-Bid antibody
Product Synonym Names
FP497; MGC42355; MGC15319
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Mouse
Form/Format
100 ug (0.5 mg/ml) affinity purified rabbit anti-Bid polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.
Appearance: Colorless liquid
Purity/Purification
Affinity purified
Concentration
0.5 mg/ml (lot specific)
Preparation and Storage
At -20 degree C
Shelf Life: 12 months
Molecular Weight
21,952 Da
3D Structure
ModBase 3D Structure for P70444
Immunogen
Synthetic peptide surrounding amino acid 45 of mouse Bid
Handling
The antibody solution should be gently mixed before use.
Applications Tested/Suitable for anti-Bid antibody
Western Blot (WB)
Application Notes for anti-Bid antibody
Western blot analysis (0.5-5 ug/ml) also works well in immunoprecipitation (20 ug/ml) and Immunohistochemistry (20 ug/ml). However, the optimal conditions should be determined individually. The antibody detects the full length (22 kDa) mouse Bid. Reactivity to other species has not been tested.

Testing Data of anti-Bid antibody

Rabbit Anti-BID Polyclonal Antibody – Cat# MBS840806

Other Notes

Small volumes of anti-Bid antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Bid purchase

MBS840806 is an antibody targeting Bid. Also known as Bid Antibody. Reactive in Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for Bid. It may not necessarily be applicable to this product.

NCBI GI #
31542228
NCBI GeneID
12122
NCBI Accession #
NP_031570.2
UniProt Primary Accession #
P70444
UniProt Secondary Accession #
Q99M39
UniProt Related Accession #
P70444
GenBank Nucleotide #
NM_007544.3
NCBI Official Full Name
BH3-interacting domain death agonist
NCBI Official Synonym Full Names
BH3 interacting domain death agonist
NCBI Official Symbol
Bid
NCBI Official Synonym Symbols
AI875481; AU022477; 2700049M22Rik
UniProt Protein Name
BH3-interacting domain death agonist
UniProt Synonym Protein Names
p22 BID; BID
Protein Family
BH3-interacting domain death agonist
UniProt Gene Name
Bid
UniProt Synonym Gene Names
BID
UniProt Entry Name
BID_MOUSE
NCBI Protein Information
BH3-interacting domain death agonist

UniProt Comments for Bid

BID: a pro-apoptotic member of the Bcl-2 superfamily. Targets intracellular membranes and contains a BH3 death domain. Heterodimerizes with either the pro-apoptotic protein BAX or the anti-apoptotic protein BCL2, antagonizing its protective effect. The activity of BID is regulated by Caspase 8-mediated cleavage, exposing the BH3 domain and significantly changing the surface charge and hydrophobicity, causing translocation to mitochondria where it triggers cytochrome c release. Multiple alternatively spliced variants have been found.

Protein type: Apoptosis; Mitochondrial

Cellular Component: membrane; mitochondrion; cell; cytoplasm; intracellular; cytosol

Molecular Function: protein binding; ubiquitin protein ligase binding

Biological Process: caspase activation; regulation of apoptosis; positive regulation of protein oligomerization; apoptotic mitochondrial changes; release of cytochrome c from mitochondria; positive regulation of apoptosis; positive regulation of protein homooligomerization; apoptosis; DNA damage response, signal transduction; regulation of protein oligomerization; protein targeting to mitochondrion; protein homooligomerization; regulation of cell proliferation
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Research Articles on Bid

1. important mediator of hepatic ischemia-reperfusion injury in both lean and steatotic livers

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-Bid antibody

 Reference Product  PubMed Publications
 Casp8 antibody  >1230 publications with Bid and Casp8
 Bax antibody  >1189 publications with Bid and Bax
 Bcl2l1 antibody  >351 publications with Bid and Bcl2l1
 Fasl antibody  >164 publications with Bid and Fasl
 Bak1 antibody  >119 publications with Bid and Bak1
 Bcl2 antibody  >118 publications with Bid and Bcl2
 Gzmb antibody  >62 publications with Bid and Gzmb
 Mcl1 antibody  >34 publications with Bid and Mcl1

Pathways associated with anti-Bid antibody

 Products by Pathway  Pathway Diagram
 Activation And Oligomerization Of BAK Protein Pathway antibodies  Activation And Oligomerization Of BAK Protein Pathway Diagram
 Activation Of BAD And Translocation To Mitochondria Pathway antibodies  Activation Of BAD And Translocation To Mitochondria Pathway Diagram
 Activation Of BH3-only Proteins Pathway antibodies  Activation Of BH3-only Proteins Pathway Diagram
 Activation, Myristolyation Of BID And Translocation To Mitochondria Pathway antibodies  Activation, Myristolyation Of BID And Translocation To Mitochondria Pathway Diagram
 Activation, Translocation And Oligomerization Of BAX Pathway antibodies  Activation, Translocation And Oligomerization Of BAX Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram

Diseases associated with anti-Bid antibody

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >924 publications with Bid and Cardiovascular Diseases
 Lung Diseases Antibodies  >708 publications with Bid and Lung Diseases
 Necrosis Antibodies  >703 publications with Bid and Necrosis
 Nervous System Diseases Antibodies  >649 publications with Bid and Nervous System Diseases
 Pain Antibodies  >482 publications with Bid and Pain
 Heart Diseases Antibodies  >463 publications with Bid and Heart Diseases
 Diarrhea Antibodies  >369 publications with Bid and Diarrhea
 Hypertension Antibodies  >331 publications with Bid and Hypertension
 Liver Diseases Antibodies  >326 publications with Bid and Liver Diseases
 Inflammation Antibodies  >303 publications with Bid and Inflammation

Organs/Tissues associated with anti-Bid antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1968 publications with Bid and Blood
 Liver Antibodies  >611 publications with Bid and Liver
 Heart Antibodies  >559 publications with Bid and Heart
 Lung Antibodies  >551 publications with Bid and Lung
 Brain Antibodies  >409 publications with Bid and Brain
 Kidney Antibodies  >292 publications with Bid and Kidney
 Skin Antibodies  >265 publications with Bid and Skin
 Bone Antibodies  >218 publications with Bid and Bone
 Muscle Antibodies  >199 publications with Bid and Muscle
 Stomach Antibodies  >197 publications with Bid and Stomach
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