Jagged 1 (JAG1) Antibody – Rabbit Polyclonal

JAG1: Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation. Enhances fibroblast growth factor-induced angiogenesis (in vitro). Interacts with NOTCH2 and NOTCH3. Interacts with NOTCH1 (in the presence of calcium ions). Widely expressed in adult and fetal tissues. In cervix epithelium expressed in undifferentiated subcolumnar reserve cells and squamous metaplasia. Expression is up-regulated in cervical squamous cell carcinoma. Expressed in bone marrow cell line HS-27a which supports the long-term maintenance of immature progenitor cells.

Protein type: Membrane protein, integral

Cellular Component: adherens junction; apical part of cell; apical plasma membrane; plasma membrane

Molecular Function: Notch binding; protein binding

Biological Process: auditory receptor cell differentiation; blood vessel remodeling; camera-type eye development; inner ear development; morphogenesis of an epithelial sheet; negative regulation of cell differentiation; negative regulation of fat cell differentiation; negative regulation of neuron differentiation; Notch signaling pathway; organ morphogenesis; organ regeneration; positive regulation of myeloid cell differentiation; positive regulation of Notch signaling pathway; positive regulation of osteoblast differentiation; positive regulation of transcription from RNA polymerase II promoter; regulation of cell proliferation; response to muramyl dipeptide; T cell mediated immunity