Rabbit Anti-HSP105 Polyclonal Antibody – Cat# MBS840835

HSP105 Antibody – Rabbit Polyclonal

Name: HSP105 Antibody; Polyclonal; Rabbit; Human/Mouse/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS840835
Price: 215 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS840835

Background: Heat shock proteins (HSPs) are ubiquitously expressed in all organisms. The HSPs fall into five general families: HSP105, HSP90, HSP70, the low molecular weight HSPs, and the immunophilins. The HSP105 (also called HSP110) family is composed of… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

Hsp105, Polyclonal Antibody

Full Product Name

Hsp105 Antibody

Product Gene Name

anti-Hsp105 antibody

Product Synonym Names

HSP 110 family; HSP 105 famioy; heat shock protein

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Form/Format

100 ug (0.2 mg/ml) Protein A purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.
Appearance: Colorless liquid

Purity/Purification

Affinity purified

Concentration

0.2 mg/ml (lot specific)

Preparation and Storage

At -20 degree C
Shelf Life: 12 months

Molecular Weight

97,460 Da

OMIM

610703

3D Structure

ModBase 3D Structure for Q92598

Immunogen

Synthetic peptide corresponding to N-terminus of mouse Hsp105

Handling

The antibody solution should be gently mixed before use.

Applications Tested/Suitable for anti-Hsp105 antibody

Western Blot (WB), Immunocytochemistry (ICC), Immunoprecipitation (IP)

Application Notes for anti-Hsp105 antibody

Western blotting (0.5-4 ug/ml), immunoprecipitation (10-20 ug/ml) and Immunohistochemistry (10-20 ug/ml). However, the optimal concentrations should be determined individually.

Other Notes

Small volumes of anti-Hsp105 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Hsp105 purchase

MBS840835 is an antibody targeting Hsp105. Also known as Hsp105 Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for Hsp105. It may not necessarily be applicable to this product.

NCBI GI #

557357685

NCBI GeneID

10808

NCBI Accession #

NP_001273432.1

UniProt Primary Accession #

Q92598

UniProt Secondary Accession #

O95739; Q5TBM6; Q5TBM7; Q5TBM8; Q9UPC4; B4DYH1

UniProt Related Accession #

Q92598

GenBank Nucleotide #

NM_001286503.1

NCBI Official Full Name

heat shock protein 105 kDa isoform 2

NCBI Official Synonym Full Names

heat shock 105kDa/110kDa protein 1

NCBI Official Symbol

HSPH1

NCBI Official Synonym Symbols

HSP105; HSP105A; HSP105B; NY-CO-25

UniProt Protein Name

Heat shock protein 105 kDa

UniProt Synonym Protein Names

Antigen NY-CO-25; Heat shock 110 kDa protein

UniProt Gene Name

HSPH1

UniProt Synonym Gene Names

HSP105; HSP110; KIAA0201

UniProt Entry Name

HS105_HUMAN

NCBI Protein Information

heat shock protein 105 kDa

UniProt Comments for Hsp105

HSP105: a molecular chaperone of the heat shock protein 70 family. Has ATPase activity. Expressed at especially high levels in mammalian brain and has been shown to suppress apoptosis in neuronal cells and to prevent the aggregation of proteins following heat shock. Known to interact with a variety of proteins including alpha-tubulin and the androgen receptor. Two alternatively spliced isoforms have been described.

Protein type: Heat shock protein; Chaperone

Chromosomal Location of Human Ortholog: 13q12.3

Cellular Component: nucleoplasm; microtubule; cytoplasm; extracellular region; cytosol

Molecular Function: protein binding; ATP binding; alpha-tubulin binding

Biological Process: receptor-mediated endocytosis; positive regulation of NK T cell activation; chaperone cofactor-dependent protein folding; positive regulation of MHC class I biosynthetic process; response to unfolded protein

Research Articles on Hsp105

1. HSP105 depletion disrupts the integration of protein phosphatase 2A into the beta-catenin degradation complex, favoring the hyperphosphorylation and degradation of beta-catenin.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.