Rabbit Anti-SMC2 Polyclonal Antibody – Cat# MBS840841

SMC2 Antibody – Rabbit Polyclonal

Name: SMC2 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS840841
Price: 375 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS840841

Background: Structural maintenance of chromosomes (SMC) proteins are part of the cohesin and condensin multisubunit complexes that play a critical role in chromosome organization, segregation, gene regulation, and DNA repair. The core condensin complex… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

SMC2, Polyclonal Antibody

Full Product Name

SMC2 Antibody

Product Gene Name

anti-SMC2 antibody

Product Synonym Names

SMC2; structural maintenance of chromosomes 2; SMC2L1; structural maintenance of chromosomes 2-like 1; CAPE; CAP-E; hCAP-E; human chromosome-associated protein E

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

100 ul affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 1% BSA and 0.02% thimerosal.
Appearance: Colorless liquid

Purity/Purification

Affinity purified

Preparation and Storage

At -20 degree C
Shelf Life: 12 months

Molecular Weight

124,926 Da

OMIM

605576

Immunogen

Synthetic peptide of human SMC2

Handling

The antibody solution should be gently mixed before use.

Applications Tested/Suitable for anti-SMC2 antibody

Western Blot (WB)

Application Notes for anti-SMC2 antibody

Western blotting (1:500 - 1:2000). However, the optimal concentrations should be determined individually. HEK293T cell lysate can be used as a positive control.The antibody recognizes the SMC2 of human origin. Reactivity to other species has not been tested.

Other Notes

Small volumes of anti-SMC2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SMC2 purchase

MBS840841 is an antibody targeting SMC2. Also known as SMC2 Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SMC2. It may not necessarily be applicable to this product.

NCBI GI #

5453591

NCBI GeneID

10592

NCBI Accession #

NP_006435.1

UniProt Secondary Accession #

Q6IEE0; Q9P1P2

UniProt Related Accession #

O95347

GenBank Nucleotide #

NM_006444.1

NCBI Official Full Name

structural maintenance of chromosomes 2-like 1

NCBI Official Synonym Full Names

structural maintenance of chromosomes 2

NCBI Official Symbol

SMC2

NCBI Official Synonym Symbols

CAPE; CAP-E; SMC-2; SMC2L1

UniProt Protein Name

Structural maintenance of chromosomes protein 2

UniProt Synonym Protein Names

Chromosome-associated protein E; hCAP-E; XCAP-E homolog

UniProt Gene Name

SMC2

UniProt Synonym Gene Names

CAPE; SMC2L1; SMC protein 2; SMC-2; hCAP-E

UniProt Entry Name

SMC2_HUMAN

NCBI Protein Information

structural maintenance of chromosomes protein 2

NCBI Summary for SMC2

Members of the structural maintenance of chromosomes, or SMC, family (e.g., SMC1A; MIM 300040) are critical for mitotic chromosome condensation in frogs and for DNA repair in mammals.[supplied by OMIM, Nov 2010]

UniProt Comments for SMC2

SMC2L1: Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. Forms an heterodimer with SMC4. Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: BRRN1/CAPH, CNAP1/CAPD2 and CAPG. Belongs to the SMC family. SMC2 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell cycle regulation

Chromosomal Location of Human Ortholog: 9q31.1

Cellular Component: nucleoplasm; nuclear chromosome; cytoplasm; condensin complex; condensed chromosome; nucleus; cytosol

Molecular Function: protein binding; protein heterodimerization activity; ATP binding

Biological Process: meiotic chromosome condensation; cell division; mitotic chromosome condensation; mitotic cell cycle; meiotic chromosome segregation; kinetochore organization and biogenesis

Research Articles on SMC2

1. SMC2 gene is altered by both frameshift mutation and loss of expression in gastric and colorectal cancers, suggesting that SMC2 gene alterations might be involved in pathogenesis of these cancers

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.