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HDAC10 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS840863

Background: HDAC family are divided into two classes, I and II. Class I of the HDAC family comprises four members, HDAC-1, 2, 3, and 8. Class II of the HDAC family comprises HDAC-4, 5, 6, and 7, the molecular weights of which are all about two-fold larger… More details

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Product Overview

Product Name
HDAC10, Polyclonal Antibody
Full Product Name
HDAC10 Antibody
Product Gene Name
anti-HDAC10 antibody
Product Synonym Names
HD10; Histone deacetylase 10
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
100 ug (0.2 mg/ml) affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.
Appearance: Colorless liquid
Purity/Purification
Affinity purified
Concentration
0.2 mg/ml (lot specific)
Preparation and Storage
At -20 degree C
Shelf Life: 12 months
Molecular Weight
43,016 Da
OMIM
608544
Immunogen
Synthetic peptide near the N-terminus of human HDAC-10
Handling
The antibody solution should be gently mixed before use.
Applications Tested/Suitable for anti-HDAC10 antibody
Western Blot (WB)
Application Notes for anti-HDAC10 antibody
Western blotting (0.5-4 ug/ml), However, the optimal concentrations should be determined individually. The antibody recognizes 74 kDa HDAC-10 of human, mouse, and rat origins. A 55 kDa cleavage fragment can also be detected in mouse and rat tissue lysates.

Testing Data of anti-HDAC10 antibody

Rabbit Anti-HDAC10 Polyclonal Antibody – Cat# MBS840863

Other Notes

Small volumes of anti-HDAC10 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for HDAC10 purchase

MBS840863 is an antibody targeting HDAC10. Also known as HDAC10 Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for HDAC10. It may not necessarily be applicable to this product.

NCBI GI #
16903566
NCBI GeneID
83933
NCBI Accession #
AAL30513
UniProt Secondary Accession #
Q08AP4; Q6STF9; Q96P77; Q96P78; Q9H028; Q9UGX1; Q9UGX2
UniProt Related Accession #
Q969S8
NCBI Official Full Name
histone deacetylase 10
NCBI Official Synonym Full Names
histone deacetylase 10
NCBI Official Symbol
HDAC10
NCBI Official Synonym Symbols
HD10
UniProt Protein Name
Histone deacetylase 10
Protein Family
Histone deacetylase
UniProt Gene Name
HDAC10
UniProt Synonym Gene Names
HD10
UniProt Entry Name
HDA10_HUMAN
NCBI Protein Information
histone deacetylase 10

NCBI Summary for HDAC10

The protein encoded by this gene belongs to the histone deacetylase family, members of which deacetylate lysine residues on the N-terminal part of the core histones. Histone deacetylation modulates chromatin structure, and plays an important role in transcriptional regulation, cell cycle progression, and developmental events. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
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UniProt Comments for HDAC10

HDAC10: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Belongs to the histone deacetylase family. HD type 2 subfamily. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.5.1.98; Transcription factor; Deacetylase

Chromosomal Location of Human Ortholog: 22q13.31

Cellular Component: nucleoplasm; cytoplasm; histone deacetylase complex; nucleus

Molecular Function: protein binding; NAD-dependent histone deacetylase activity (H3-K9 specific); enzyme binding; NAD-dependent histone deacetylase activity (H3-K14 specific); histone deacetylase binding; protein deacetylase activity; NAD-dependent histone deacetylase activity (H4-K16 specific); histone deacetylase activity

Biological Process: establishment and/or maintenance of chromatin architecture; Notch signaling pathway; transcription, DNA-dependent; protein amino acid deacetylation; regulation of transcription, DNA-dependent; histone deacetylation; chromatin modification; negative regulation of transcription from RNA polymerase II promoter; oligodendrocyte development; negative regulation of transcription, DNA-dependent
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Research Articles on HDAC10

1. Suggest HDAC10 expression as a prognostic marker for gastric cancer.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
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