Rabbit Anti-HDAC7 Polyclonal Antibody – Cat# MBS840870

HDAC7 Antibody – Rabbit Polyclonal

Name: HDAC7 Antibody; Polyclonal; Rabbit; Human/Mouse/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS840870
Price: 215 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS840870

Background: Human HDAC7 is composed of 912 amino acid residues. Althomugh HDAC7 is localized mostly to the cell nucleus, it is also found in the cytoplasm, smuggesting nucleo-cytoplasmic shuttling. The histone deacetylase activity of HDAC7 maps to a… More details

DISCONTINUED
Click here to view our similar product(s) OR click here to contact our technical support team for suitable replacement.

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

HDAC7, Polyclonal Antibody

Full Product Name

HDAC7 Antibody

Product Gene Name

anti-HDAC7 antibody

Product Synonym Names

HDAC7A; histone deacetylase 7A

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Form/Format

100 ug (0.2 mg/ml) affinity purified rabbit anti-HDAC7 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.
Appearance: Colorless liquid

Purity/Purification

Affinity purified

Concentration

0.2 mg/ml (lot specific)

Preparation and Storage

At -20 degree C
Shelf Life: 12 months

Molecular Weight

98,752 Da

3D Structure

ModBase 3D Structure for Q8C2B3

Immunogen

Synthetic peptide surrounding amino acid 921 of murine HDAC7

Handling

The antibody solution should be gently mixed before use.

Applications Tested/Suitable for anti-HDAC7 antibody

Western Blot (WB), Immunocytochemistry (ICC), Immunoprecipitation (IP)

Application Notes for anti-HDAC7 antibody

Western blotting (0.5-4 ug/ml), immunoprecipitation (20-40 ug/ml) and Immunohistochemistry (20-40 ug/ml). However, the optimal conditions should be determined individually. The antibody detects ~105 kDa HDAC7. Mouse small intestine tissue lysate can be use as a positive control. The antibody does not recognize other members of the HDAC family.

Other Notes

Small volumes of anti-HDAC7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for HDAC7 purchase

MBS840870 is an antibody targeting HDAC7. Also known as HDAC7 Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for HDAC7. It may not necessarily be applicable to this product.

NCBI GI #

324073114

NCBI GeneID

56233

NCBI Accession #

NP_001191204.1

UniProt Primary Accession #

Q8C2B3

UniProt Secondary Accession #

Q8C2C9; Q8C8X4; Q8CB80; Q8CDA3; Q9JL72

UniProt Related Accession #

Q8C2B3

GenBank Nucleotide #

NM_001204275.1

NCBI Official Full Name

histone deacetylase 7 isoform 1

NCBI Official Synonym Full Names

histone deacetylase 7

NCBI Official Symbol

Hdac7

NCBI Official Synonym Symbols

HD7; HD7a; Hdac7a; mFLJ00062; 5830434K02Rik

UniProt Protein Name

Histone deacetylase 7

UniProt Synonym Protein Names

Histone deacetylase 7A; HD7a

UniProt Gene Name

Hdac7

UniProt Synonym Gene Names

Hdac7a; HD7; HD7a

UniProt Entry Name

HDAC7_MOUSE

NCBI Protein Information

histone deacetylase 7

UniProt Comments for HDAC7

HDAC7: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene. Interacts with HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, NCOR1, NCOR2, SIN3A, SIN3B, RBBP4, RBBP7, MTA1L1, SAP30 and MBD3. Interacts with the 14-3-3 protein YWHAE, MEF2A, MEF2B and MEF2C. Interacts with KAT5 and EDNRA. Interacts with KDM5B. Interacts with ZMYND15. Belongs to the histone deacetylase family. HD type 2 subfamily. 10 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.5.1.98; Hydrolase

Cellular Component: cytoplasm; histone deacetylase complex; nucleus

Molecular Function: transcription activator binding; hydrolase activity; metal ion binding; transcription factor binding; protein kinase binding; histone deacetylase activity (H3-K14 specific); histone deacetylase activity (H3-K9 specific); NAD-dependent histone deacetylase activity (H3-K9 specific); protein binding; protein kinase C binding; NAD-dependent histone deacetylase activity (H3-K14 specific); chromatin binding; NAD-dependent histone deacetylase activity (H4-K16 specific); histone deacetylase activity; transcription corepressor activity

Biological Process: intercellular junction assembly; nervous system development; B cell activation; transcription, DNA-dependent; histone deacetylation; chromatin modification; negative regulation of transcription from RNA polymerase II promoter; negative regulation of striated muscle development; negative regulation of interleukin-2 production; regulation of transcription, DNA-dependent; B cell differentiation; negative regulation of osteoblast differentiation; negative regulation of transcription, DNA-dependent; inflammatory response; vasculogenesis

Research Articles on HDAC7

1. Hdac7 degradation enhances beta-catenin transcriptional activity in growth plate chondrocytes.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.