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HDAC8 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS840922

Background: Mammalian HDAC-8, isolated from human kidney, is a member of the histone deacetylase family. HDAC-8 shares homology with other HDACs in the family, but has different tissue distribution. HDAC-8 is localized to the nucleus and plays a role in the… More details

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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Product Name
HDAC8, Polyclonal Antibody
Full Product Name
HDAC8 Antibody
Product Gene Name
anti-HDAC8 antibody
Product Synonym Names
HD8; RPD3; HDACL1
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
100 ug (0.2 mg/ml) protein A purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.
Appearance: Colorless liquid
Purity/Purification
Affinity purified
Concentration
0.2 mg/ml (lot specific)
Preparation and Storage
At -20 degree C
Shelf Life: 12 months
Molecular Weight
28,122 Da
3D Structure
ModBase 3D Structure for Q8VH37
Immunogen
Synthetic peptide surrounding amino acid 10 of mouse HDAC-8
Handling
The antibody solution should be gently mixed before use.
Applications Tested/Suitable for anti-HDAC8 antibody
Western Blot (WB), Immunocytochemistry (ICC), Immunoprecipitation (IP)
Application Notes for anti-HDAC8 antibody
Western blotting (0.5-4 ug/ml), immunoprecipitation (10-20 ug/ml), and Immunohistochemistry (10-20 ug/ml). However, the optimal concentrations should be determined individually.

Testing Data of anti-HDAC8 antibody

Rabbit Anti-HDAC8 Polyclonal Antibody – Cat# MBS840922

Other Notes

Small volumes of anti-HDAC8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for HDAC8 purchase

MBS840922 is an antibody targeting HDAC8. Also known as HDAC8 Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for HDAC8. It may not necessarily be applicable to this product.

NCBI GI #
58037203
NCBI GeneID
70315
NCBI Accession #
NP_081658.1
UniProt Primary Accession #
Q8VH37
UniProt Secondary Accession #
Q3V270; Q9D0K6
UniProt Related Accession #
Q8VH37
GenBank Nucleotide #
NM_027382.3
NCBI Official Full Name
histone deacetylase 8
NCBI Official Synonym Full Names
histone deacetylase 8
NCBI Official Symbol
Hdac8
NCBI Official Synonym Symbols
2610007D20Rik
UniProt Protein Name
Histone deacetylase 8
UniProt Gene Name
Hdac8
UniProt Synonym Gene Names
HD8
UniProt Entry Name
HDAC8_MOUSE
NCBI Protein Information
histone deacetylase 8

UniProt Comments for HDAC8

HDAC8: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. May play a role in smooth muscle cell contractility. Belongs to the histone deacetylase family. HD type 1 subfamily. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.5.1.98; Hydrolase

Cellular Component: cytoplasm; histone deacetylase complex; plasma membrane; nucleus

Molecular Function: histone deacetylase activity (H3-K9 specific); histone deacetylase activity (H3-K14 specific); NAD-dependent histone deacetylase activity (H3-K9 specific); hydrolase activity; NAD-dependent histone deacetylase activity (H3-K14 specific); metal ion binding; NAD-dependent histone deacetylase activity (H4-K16 specific); histone deacetylase activity; transcription factor binding

Biological Process: transcription, DNA-dependent; regulation of transcription, DNA-dependent; sister chromatid cohesion; histone deacetylation; chromatin modification
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Research Articles on HDAC8

1. histone deacetylase 8 inhibition reduces gene expression and production of proinflammatory cytokines in vitro and in vivo

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
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