Rabbit Anti-MMP-8 Polyclonal Antibody – Cat# MBS840924

MMP-8 Antibody – Rabbit Polyclonal

Name: MMP-8 Antibody; Polyclonal; Rabbit; Human/Mouse/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS840924
Price: 390 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS840924

Background: The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, fibronectin, laminin and proteoglycan. Transcription of MMP genes is… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

MMP-8, Polyclonal Antibody

Full Product Name

MMP-8 Antibody

Product Gene Name

anti-MMP-8 antibody

Product Synonym Names

120355; P22894; CLG1; HNC; PMNL-CL; EC 3.4.24.34; MMP-8; Matrix metalloproteinase

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Form/Format

100 ug (0.5 mg/ml) protein A affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 50% glycerol, 1% BSA, and 0.02% thimerosal.
Appearance: Colorless liquid

Purity/Purification

Affinity purified

Concentration

0.5 mg/ml (lot specific)

Preparation and Storage

At -20 degree C
Shelf Life: 12 months

Molecular Weight

53,412 Da

OMIM

120355

3D Structure

ModBase 3D Structure for P22894

Immunogen

Synthetic peptide mapping to the hinge region of the human MMP-8 sequence

Handling

The antibody solution should be gently mixed before use.

Applications Tested/Suitable for anti-MMP-8 antibody

Western Blot (WB), Immunoprecipitation (IP), Immunofluorescence (IF), Immunohistochemistry (IHC)

Application Notes for anti-MMP-8 antibody

Western blotting (1-4 ug/ml), immunoprecipitation (10-20 ug/ml), and Immunohistochemistry (15-25 ug/ml). However, the optimal concentrations should be determined individually. The antibody recognizes latent (85 kDa) and active forms (25-65 kDa) of MMP8 from human, mouse, and rat origins.

Other Notes

Small volumes of anti-MMP-8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MMP-8 purchase

MBS840924 is an antibody targeting MMP-8. Also known as MMP-8 Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for MMP-8. It may not necessarily be applicable to this product.

NCBI GI #

751247063

NCBI GeneID

4317

NCBI Accession #

NP_001291370.1

UniProt Primary Accession #

P22894

UniProt Secondary Accession #

Q45F99

UniProt Related Accession #

P22894

GenBank Nucleotide #

NM_001304441.1

NCBI Official Full Name

neutrophil collagenase isoform 2

NCBI Official Synonym Full Names

matrix metallopeptidase 8

NCBI Official Symbol

MMP8

NCBI Official Synonym Symbols

HNC; CLG1; MMP-8; PMNL-CL

UniProt Protein Name

Neutrophil collagenase

UniProt Synonym Protein Names

Matrix metalloproteinase-8; MMP-8; PMNL collagenase; PMNL-CL

Protein Family

Neutrophil collagenase

UniProt Gene Name

MMP8

UniProt Synonym Gene Names

CLG1; MMP-8; PMNL-CL

UniProt Entry Name

MMP8_HUMAN

NCBI Protein Information

neutrophil collagenase

NCBI Summary for MMP-8

This gene encodes a member of the matrix metalloproteinase (MMP) family of proteins. These proteins are involved in the breakdown of extracellular matrix in embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Proteolysis at different sites on this protein results in multiple active forms of the enzyme with distinct N-termini. This protein functions in the degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

UniProt Comments for MMP-8

MMP8: Can degrade fibrillar type I, II, and III collagens. Belongs to the peptidase M10A family.

Protein type: EC 3.4.24.34; Secreted, signal peptide; Secreted; Protease

Chromosomal Location of Human Ortholog: 11q22.3

Cellular Component: proteinaceous extracellular matrix; extracellular space; extracellular region

Molecular Function: zinc ion binding; metalloendopeptidase activity; serine-type endopeptidase activity; calcium ion binding

Biological Process: extracellular matrix disassembly; collagen catabolic process; extracellular matrix organization and biogenesis; proteolysis

Research Articles on MMP-8

1. Strong associations of MMP-8 with components of Metabolic Syndrome X in univariate, bivariate and multivariate models suggest plasma MMP-8 as a potential cardiometabolic risk marker for Metabolic syndrome X.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.