Rabbit Anti-MCAK Polyclonal Antibody – Cat# MBS840938

MCAK Antibody – Rabbit Polyclonal

Name: MCAK Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS840938
Price: 375 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS840938

Background: Kinesin activity has been linked to various cellular functions such as vesicle transport, mitotic spindle formation, chromosome segregation, chromosome congression, and cytokinesis. Structurally, all kinesins contain a motor domain with… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

MCAK, Polyclonal Antibody

Full Product Name

MCAK Antibody

Product Gene Name

anti-MCAK antibody

Product Synonym Names

MCAK; Mitotic Centromere-Associated Kinesin; KIF2C; Kinesein Family Member 2C; KNSL6; Kinesin-Like 6; ESTM5

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

100 ul affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 1% BSA and 0.02% thimerosal.
Appearance: Colorless liquid

Purity/Purification

Affinity purified

Preparation and Storage

At -20 degree C
Shelf Life: 12 months

Molecular Weight

75,561 Da

OMIM

604538

Immunogen

Synthetic peptide of human MCAK

Handling

The antibody solution should be gently mixed before use.

Applications Tested/Suitable for anti-MCAK antibody

Western Blot (WB), Immunoprecipitation (IP)

Application Notes for anti-MCAK antibody

Western blotting (1:500 - 1:2000) and Immunoprecipitation. HeLa cell lysate can be used as a positive control. However, the optimal concentrations should be determined individually. The antibody recognizes the MCAK of human origin. Reactivity to other species has not been tested.

Other Notes

Small volumes of anti-MCAK antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MCAK purchase

MBS840938 is an antibody targeting MCAK. Also known as MCAK Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for MCAK. It may not necessarily be applicable to this product.

NCBI GI #

5803082

NCBI GeneID

11004

NCBI Accession #

NP_006836.1

UniProt Secondary Accession #

Q5JR88; Q6ICU1; Q96C18; Q96HB8; Q9BWV8; B3ITR9

UniProt Related Accession #

Q99661

GenBank Nucleotide #

NM_006845.2

NCBI Official Full Name

kinesin family member 2C

NCBI Official Synonym Full Names

kinesin family member 2C

NCBI Official Symbol

KIF2C

NCBI Official Synonym Symbols

MCAK; CT139; KNSL6

UniProt Protein Name

Kinesin-like protein KIF2C

UniProt Synonym Protein Names

Kinesin-like protein 6; Mitotic centromere-associated kinesin; MCAK

UniProt Gene Name

KIF2C

UniProt Synonym Gene Names

KNSL6; MCAK

UniProt Entry Name

KIF2C_HUMAN

NCBI Protein Information

kinesin-like protein KIF2C

NCBI Summary for MCAK

This gene encodes a kinesin-like protein that functions as a microtubule-dependent molecular motor. The encoded protein can depolymerize microtubules at the plus end, thereby promoting mitotic chromosome segregation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

UniProt Comments for MCAK

KIF2C: In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis. Belongs to the kinesin-like protein family. MCAK/KIF2 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Microtubule-binding; Cancer Testis Antigen (CTA); Motor; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 1p34.1

Cellular Component: kinetochore; microtubule cytoskeleton; kinesin complex; membrane; cytoplasmic microtubule; nucleus; cytosol; chromosome, pericentric region

Molecular Function: centromeric DNA binding; microtubule plus-end binding; protein binding; ATPase activity; microtubule motor activity; ATP binding

Biological Process: cell proliferation; mitosis; cell division; metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class II; microtubule depolymerization; regulation of chromosome segregation; mitotic cell cycle; blood coagulation; mitotic metaphase plate congression; microtubule-based movement; establishment and/or maintenance of microtubule cytoskeleton polarity

Research Articles on MCAK

1. Ras regulates KIF2C to control cell migration pathways in transformed human bronchial epithelial cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.