Rabbit Anti-HAT-2 Polyclonal Antibody – Cat# MBS840943

HAT-2 Antibody – Rabbit Polyclonal

Name: HAT-2 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS840943
Price: 215 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS840943

Background: Histone acetyltransferases (HATs) have been implicated in a number of cellular functions including gene regulation, DNA synthesis, and repair. Histone acetyltransferases and deacetylases are, respectively, the enzymes devoted to the addition and… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

HAT-2, Polyclonal Antibody

Full Product Name

HAT-2 Antibody

Product Gene Name

anti-HAT-2 antibody

Product Synonym Names

Anti-HAT-2 antibody; HAT-2 antibody; Anti-HAT-2; HAT-2; HAT; histone acetyltransferase; HATs; HDACs HAT-2 Polyclonal Antibody; Anti-HAT-2

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

100 ug (0.5 mg/ml) Protein A affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.
Appearance: Colorless liquid

Purity/Purification

Affinity purified

Concentration

0.5 mg/ml (lot specific)

Preparation and Storage

At -20 degree C
Shelf Life: 12 months

Molecular Weight

55,135 Da

OMIM

609880

Immunogen

Synthetic peptide mapping to the N-terminus of human HAT-2

Handling

The antibody solution should be gently mixed before use.

Applications Tested/Suitable for anti-HAT-2 antibody

Western Blot (WB)

Application Notes for anti-HAT-2 antibody

Western blotting (0.5-4 ug/ml). However, the optimal concentrations should be determined individually. The antibody recognizes ~65 kDa HAT-2 from human samples, and in a lesser extent, from mouse and rat samples. Jurkat cell lysate can be used as a positive control.

Other Notes

Small volumes of anti-HAT-2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for HAT-2 purchase

MBS840943 is an antibody targeting HAT-2. Also known as HAT-2 Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for HAT-2. It may not necessarily be applicable to this product.

NCBI GI #

21619719

NCBI GeneID

11143

NCBI Accession #

AAH32640

UniProt Secondary Accession #

B3KN74; B4DF85; B4DFB4; B4DFE0; B4DGY4; E7ER15; G5E9K7

UniProt Related Accession #

O95251

NCBI Official Full Name

MYST histone acetyltransferase 2

NCBI Official Synonym Full Names

K(lysine) acetyltransferase 7

NCBI Official Symbol

KAT7

NCBI Official Synonym Symbols

HBO1; HBOA; MYST2; ZC2HC7

UniProt Protein Name

Histone acetyltransferase KAT7

UniProt Synonym Protein Names

Histone acetyltransferase binding to ORC1; Lysine acetyltransferase 7; MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2; MYST-2

UniProt Gene Name

KAT7

UniProt Synonym Gene Names

HBO1; HBOa; MYST2; MYST-2

UniProt Entry Name

KAT7_HUMAN

NCBI Protein Information

histone acetyltransferase KAT7

UniProt Comments for HAT-2

MYST2: a histone acetyltransferase that participates in DNA replication and the loading of the minichromosome maintenance (Mcm) complex onto chromatin. Is required for origin recognition complex (Orc) formation and replication licensing, and is responsible for much of the acetylation of histone H4. Interacts with MCM2 and ORC1L. Phosphorylated by Cdc2 during mitosis, creating a site that recruits Plk1, which in turn phosphorylates MYST2. Its phosphorylation by Plk1 during mitosis may be required for the formation of the prereplicative complex. Interacts with the androgen receptor (AR) in the presence of dihydrotestosterone. Specifically represses AR-mediated transcription.

Protein type: EC 2.3.1.48; Nuclear receptor co-regulator; Acetyltransferase; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 17q21.32

Cellular Component: nucleoplasm; cytoplasm; nucleolus; histone acetyltransferase complex

Molecular Function: protein binding; histone acetyltransferase activity; zinc ion binding; transcription factor activity

Biological Process: establishment and/or maintenance of chromatin architecture; transcription, DNA-dependent; regulation of transcription, DNA-dependent; DNA replication

Research Articles on HAT-2

1. Myst2-mediated histone acetylation may be required for recruitment of Oct4 to the Nanog promoter

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.