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P Glycoprotein 1 (MDR1) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9601358

Description: A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the… More details

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Product Overview

Online Datasheet in PDF
Product Name
P Glycoprotein 1 (MDR1), Polyclonal Antibody
Full Product Name
P Glycoprotein 1 (MDR1) Antibody
Product Gene Name
anti-MDR1 antibody
Product Synonym Gene Name
ABCB1
Product Synonym Names
ABC20; ABCB1; ATP binding cassette, sub family B (MDR/TAP), member 1; ATP-binding cassette sub-family B member 1; CD243; CLCS; Colchicin sensitivity; Doxorubicin resistance; GP170; MDR1; MDR1_HUMAN; Multidrug resistance 1; Multidrug resistance protein 1; P glycoprotein 1; P gp; P-glycoprotein 1; PGY1
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
Concentration
1mg/ml (lot specific)
Specificity
P Glycoprotein 1(MDR1) antibody detects endogenous levels of total P Glycoprotein 1(MDR1)
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
Antibody/Peptide Pairs
P Glycoprotein 1?MDR1? peptide (MBS9616890) is used for blocking the activity of P Glycoprotein 1?MDR1? antibody (MBS9601358)
Molecular Weight
Observed: 141 kDa
Predicted: 142 kDa
3D Structure
ModBase 3D Structure for P08183
Supply Chain Verification
Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available, please inquire.
Immunogen
A synthesized peptide derived from human P Glycoprotein 1(MDR1)
Subcellular Location
Membrane.
Tissue Specificity
Expressed in liver, kidney, small intestine and brain.
Predicted Cross Reactivity
Pig, Horse, Rabbit, Dog, Chicken, Xenopus
Similarity
Pig (92%), Horse (83%), Rabbit (100%), Dog (100%), Chicken (83%), Xenopus (83%)
Conjugation
Unconjugated
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-MDR1 antibody
Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)
Application Notes for anti-MDR1 antibody
WB: 1:500-1:1000
IHC: 1:50-1:200

Immunohistochemistry (IHC) of anti-MDR1 antibody

MBS9601358 for IHC in human brain tissue
Rabbit Anti-MDR1 Polyclonal Antibody – Cat# MBS9601358

Western Blot (WB) of anti-MDR1 antibody

Western blot analysis of MDR1 using HT-29 whole cell lysates, The lane on the left is treated with the antigen-specific peptide.
Rabbit Anti-MDR1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS9601358

Product References and Citations for anti-MDR1 antibody

Shao Q, Zhang P, Ma Y, Lu Z, Meng J, Li H, Wang X, Chen D, Zhang M, Han Y, Liu H, Ma S; Journal: Gene. MicroRNA-139-5p affects cisplatin sensitivity in human nasopharyngeal carcinoma cells by regulating the epithelial-to-mesenchymal transition. Liu Y, Tang J, Liu D, Zhang L, He Y, Li J, Gao L, Tang D, Jin X, Kong D; Journal: Cell Death Dis. Increased autophagy in EOC re-ascites cells can inhibit cell death and promote drug resistance. Zhou H, Lin C, Zhang Y, Zhang X, Zhang C, Zhang P, Xie X, Ren Z; Journal: Cell Prolif. miR-506 enhances the sensitivity of human colorectal cancer cells to oxaliplatin by suppressing MDR1/P-gp expression. Xiang Y, Ye W, Huang C, Yu D, Chen H, Deng T, Zhang F, Lou B, Zhang J, Shi K, Chen B, Zhou M; Journal: Oxid Med Cell Longev. Brusatol Enhances the Chemotherapy Efficacy of Gemcitabine in Pancreatic Cancer via the Nrf2 Signalling Pathway.

Other Notes

Small volumes of anti-MDR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MDR1 purchase

MBS9601358 is an antibody targeting MDR1. Also known as P Glycoprotein 1 (MDR1) Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for MDR1. It may not necessarily be applicable to this product.

NCBI GI #
42741659
NCBI GeneID
5243
NCBI Accession #
NP_000918.2
UniProt Primary Accession #
P08183
UniProt Secondary Accession #
Q12755; Q14812; A8K294; B5AK60
UniProt Related Accession #
P08183
GenBank Nucleotide #
NM_000927.4
NCBI Official Full Name
multidrug resistance protein 1 isoform 2
NCBI Official Synonym Full Names
ATP binding cassette subfamily B member 1
NCBI Official Symbol
ABCB1
NCBI Official Synonym Symbols
CLCS; MDR1; P-GP; PGY1; ABC20; CD243; GP170
UniProt Protein Name
Multidrug resistance protein 1
UniProt Synonym Protein Names
ATP-binding cassette sub-family B member 1; P-glycoprotein 1; CD_antigen: CD243
Protein Family
Benomyl/methotrexate resistance protein
UniProt Gene Name
ABCB1
UniProt Synonym Gene Names
MDR1; PGY1
NCBI Protein Information
multidrug resistance protein 1

NCBI Summary for MDR1

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. Mutations in this gene are associated with colchicine resistance and Inflammatory bowel disease 13. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Feb 2017]
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UniProt Comments for MDR1

Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.

Research Articles on MDR1

1. 13-cis-retinoic acid, retinol and retinyl-acetate inhibited the Pgp and ABCG2 mediated substrate transport as well as the substrate stimulated ATPase activity of these transporters.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MDR1 antibody

 Reference Product  PubMed Publications
 HIF1A antibody  >47 publications with MDR1 and HIF1A
 TP53 antibody  >33 publications with MDR1 and TP53
 SP1 antibody  >30 publications with MDR1 and SP1
 SLC22A1 antibody  >26 publications with MDR1 and SLC22A1
 CAV1 antibody  >25 publications with MDR1 and CAV1
 SLC22A2 antibody  >15 publications with MDR1 and SLC22A2
 NR1I3 antibody  >12 publications with MDR1 and NR1I3
 ARNT antibody  >4 publications with MDR1 and ARNT
 LANCL2 antibody  >1 publications with MDR1 and LANCL2

Pathways associated with anti-MDR1 antibody

 Products by Pathway  Pathway Diagram
 ABC Transporters Pathway antibodies  ABC Transporters Pathway Diagram
 ABC Transporters Pathway antibodies  ABC Transporters Pathway Diagram
 ABC-family Proteins Mediated Transport Pathway antibodies  ABC-family Proteins Mediated Transport Pathway Diagram
 Abacavir Transmembrane Transport Pathway antibodies  Abacavir Transmembrane Transport Pathway Diagram
 Abacavir Transport And Metabolism Pathway antibodies  Abacavir Transport And Metabolism Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Codeine And Morphine Metabolism Pathway antibodies  Codeine And Morphine Metabolism Pathway Diagram
 Drug Induction Of Bile Acid Pathway antibodies  Drug Induction Of Bile Acid Pathway Diagram
 HIF-1-alpha Transcription Factor Network Pathway antibodies  HIF-1-alpha Transcription Factor Network Pathway Diagram

Diseases associated with anti-MDR1 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >6720 publications with MDR1 and Neoplasms
 Carcinoma Antibodies  >2221 publications with MDR1 and Carcinoma
 Drug Toxicity Antibodies  >1688 publications with MDR1 and Drug Toxicity
 Gastrointestinal Diseases Antibodies  >783 publications with MDR1 and Gastrointestinal Diseases
 Nervous System Diseases Antibodies  >748 publications with MDR1 and Nervous System Diseases
 Liver Diseases Antibodies  >531 publications with MDR1 and Liver Diseases
 Epilepsy Antibodies  >310 publications with MDR1 and Epilepsy
 Carcinoma, Non-Small-Cell Lung Antibodies  >304 publications with MDR1 and Carcinoma, Non-Small-Cell Lung
 Kidney Diseases Antibodies  >280 publications with MDR1 and Kidney Diseases
 Disease Progression Antibodies  >279 publications with MDR1 and Disease Progression

Organs/Tissues associated with anti-MDR1 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >2162 publications with MDR1 and Brain
 Placenta Antibodies  >182 publications with MDR1 and Placenta
 Uterus Antibodies  >27 publications with MDR1 and Uterus
 Trachea Antibodies  >8 publications with MDR1 and Trachea
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