TLR5 Antibody – Rabbit Polyclonal

TLR5: Participates in the innate immune response to microbial agents. Mediates detection of bacterial flagellins. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Genetic variation in TLR5 is associated with resistance to systemic lupus erythematosus type 1 (SLEB1). Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a complex genetic basis. SLE is an inflammatory, and often febrile multisystemic disorder of connective tissue characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system. Belongs to the Toll-like receptor family.

Protein type: Membrane protein, integral; Receptor, misc.

Cellular Component: membrane; integral to membrane

Molecular Function: protein binding; interleukin-1 receptor binding; transmembrane receptor activity

Biological Process: toll-like receptor 5 signaling pathway; positive regulation of interleukin-8 production; positive regulation of cytokine production; MyD88-dependent toll-like receptor signaling pathway; regulation of cytokine secretion; positive regulation of nitric oxide biosynthetic process; immune system process; defense response to bacterium; innate immune response; signal transduction; inflammatory response; positive regulation of toll-like receptor signaling pathway