Rabbit Anti-HAT-1 Polyclonal Antibody – Cat# MBS840955

HAT-1 Antibody – Rabbit Polyclonal

Name: HAT-1 Antibody; Polyclonal; Rabbit; Human/Mouse/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS840955
Price: 215 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS840955

Background: Histone acetyltransferases (HATs) have been implicated in a number of cellular functions including gene regulation, DNA synthesis, and repair. Histone acetyltransferases and deacetylases are, respectively, the enzymes devoted to the addition and… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

HAT-1, Polyclonal Antibody

Full Product Name

HAT-1 Antibody

Product Gene Name

anti-HAT-1 antibody

Product Synonym Names

HAT 1; Histidine aminotransferase 1; Histone acetyltransferase 1; KAT1

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Form/Format

100 ug (0.2 mg/ml) immunoaffinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.
Appearance: Colorless liquid

Purity/Purification

Affinity purified

Concentration

0.2 mg/ml (lot specific)

Preparation and Storage

At -20 degree C
Shelf Life: 12 months

Molecular Weight

53,085 Da

OMIM

609912

Immunogen

Synthetic peptide surrounding amino acid 445 of human HAT-1

Handling

The antibody solution should be gently mixed before use.

Applications Tested/Suitable for anti-HAT-1 antibody

Western Blot (WB)

Application Notes for anti-HAT-1 antibody

Western blotting (1-2 ug/ml). However, the optimal concentrations should be determined individually. The antibody recognizes 50 kDa HAT-1 from samples of human, mouse and rat origins. Jurkat cell lysate can be used as a positive control.

Other Notes

Small volumes of anti-HAT-1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for HAT-1 purchase

MBS840955 is an antibody targeting HAT-1. Also known as HAT-1 Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for HAT-1. It may not necessarily be applicable to this product.

NCBI GI #

226371636

NCBI GeneID

84148

NCBI Accession #

NP_115564

UniProt Secondary Accession #

Q659G0; Q7LC17; Q8IY59; Q8WYB4; Q8WZ14; Q9HAC5; Q9NR35; A8K4Z1; G5E9P2

UniProt Related Accession #

Q9H7Z6

GenBank Nucleotide #

NM_032188.2

NCBI Official Full Name

histone acetyltransferase KAT8 isoform 1

NCBI Official Synonym Full Names

K(lysine) acetyltransferase 8

NCBI Official Symbol

KAT8

NCBI Official Synonym Symbols

MOF; hMOF; MYST1; ZC2HC8

UniProt Protein Name

Histone acetyltransferase KAT8

UniProt Synonym Protein Names

Lysine acetyltransferase 8; MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1; MYST-1; hMOF

UniProt Gene Name

KAT8

UniProt Synonym Gene Names

MOF; MYST1; MYST-1; hMOF

UniProt Entry Name

KAT8_HUMAN

NCBI Protein Information

histone acetyltransferase KAT8

NCBI Summary for HAT-1

This gene encodes a member of the MYST histone acetylase protein family. The encoded protein has a characteristic MYST domain containing an acetyl-CoA-binding site, a chromodomain typical of proteins which bind histones, and a C2HC-type zinc finger. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]

UniProt Comments for HAT-1

MYST1: Histone acetyltransferase which may be involved in transcriptional activation. May influence the function of ATM. As part of the MSL complex it is involved in acetylation of nucleosomal histone H4 producing specifically H4K16ac. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. That activity is less specific than the one of the MSL complex. Belongs to the MYST (SAS/MOZ) family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Acetyltransferase; EC 2.3.1.48

Chromosomal Location of Human Ortholog: 16p11.2

Cellular Component: nucleoplasm; kinetochore; nuclear membrane; nucleus; histone acetyltransferase complex

Molecular Function: protein binding; enzyme binding; histone acetyltransferase activity; metal ion binding; acetyltransferase activity; histone acetyltransferase activity (H4-K16 specific); transcription factor binding; methylated histone residue binding

Biological Process: establishment and/or maintenance of chromatin architecture; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; regulation of autophagy; myeloid cell differentiation; histone acetylation; negative regulation of transcription, DNA-dependent

Research Articles on HAT-1

1. The histone acetyltransferase hMOF suppresses hepatocellular carcinoma growth by targeting the expression of SIRT6.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.