MST-2/KRS-1 Antibody – Rabbit Polyclonal

This gene encodes a serine/threonine protein kinase activated by proapoptotic molecules indicating the encoded protein functions as a growth suppressor. Cleavage of the protein product by caspase removes the inhibitory C-terminal portion. The N-terminal portion is transported to the nucleus where it homodimerizes to form the active kinase which promotes the condensation of chromatin during apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

MST2: a protein kinase of the STE20 family. Activated by apoptotic signals as well as other stress conditions. Full activation requires both phosphorylation and caspase-mediated cleavage. Following cleavage by caspase-3, undergoes irreversible autophosphorylation. Full-length is mainly unphosphorylated in the rat thymus and cultured cells, whereas caspase-3-cleaved MST2 in apoptotic cells is highly phosphorylated.

Protein type: Kinase, protein; EC 2.7.11.1; Autophagy; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family; MST subfamily

Chromosomal Location of Human Ortholog: 8q22.2

Cellular Component: cytoplasm; nucleus; cytosol

Molecular Function: protein dimerization activity; protein serine/threonine kinase activator activity; protein serine/threonine kinase activity; protein binding; magnesium ion binding; ATP binding; protein kinase activity; receptor signaling protein serine/threonine kinase activity

Biological Process: central nervous system development; protein stabilization; positive regulation of protein binding; positive regulation of apoptosis; apoptosis; positive regulation of JNK cascade; negative regulation of organ growth; signal transduction; protein amino acid phosphorylation; positive regulation of protein kinase B signaling cascade; negative regulation of cell proliferation; positive regulation of fat cell differentiation; positive regulation of transcription factor activity; neural tube formation