APG12/ATG12 Antibody – Rabbit Polyclonal

Background: Autophagy, the process of bulk degradation of cellular proteins thromugh an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) thromugh phosphorylation of autophagy protein APG1. ATG12, another member of the autophagy protein family, forms a conjmugate with ATG5; this conjmugate has a ubiquitin-protein ligase (E3)-like activity for protein lipidation in autophagy. This conjmugate also associates with innate immune response proteins such as RIG-I and VISA (also known as IPS-1), inhibiting type I interferon production and permitting viral replication in host cells. ATG12 has also been shown to interact with ATG10 in human embryonic kidney cells in the presence of ATG7. At least two isoforms of ATG12 are known to exist.

Small volumes of anti-APG12/ATG12 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS841012 is an antibody targeting APG12/ATG12. Also known as APG12 / ATG12 Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.