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MMP-11 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS841071

Background: The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, fibronectin, laminin and proteoglycan. Transcription of MMP genes is… More details

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Product Overview

Product Name
MMP-11, Polyclonal Antibody
Full Product Name
MMP-11 Antibody
Product Gene Name
Product Synonym Names
ST3; SL-3; MMP-11; STMY3; Matrix metalloproteinase
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
100 ug (0.5 mg/ml) immunoaffinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.
Appearance: Colorless liquid
Purity/Purification
Affinity purified
Concentration
0.5 mg/ml (lot specific)
Preparation and Storage
At -20 degree C
Shelf Life: 12 months
Molecular Weight
55,441 Da
Immunogen
Synthetic peptide surrounding amino acid 464 of mouse MMP-11
Positive Control
Western Blot: Jurkat cell lysate. IHC: Adrenal tissue
Handling
The antibody solution should be gently mixed before use.
Applications Tested/Suitable for anti-MMP-11 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-MMP-11 antibody
Western blotting (0.5-4 ug/ml) and Immunohistochemistry (5 ug/ml). However, the optimal conditions should be determined individually. Blocking peptide (3531RBP-50) is available separately. The antibody recognizes the latent form (~68 kDa) and the active forms (~55 kDa and ~40 kDa) of MMP-11 from human, mouse, and rat origins.

Testing Data of anti-MMP-11 antibody

Rabbit Anti-MMP-11 Polyclonal Antibody – Cat# MBS841071

Other Notes

Small volumes of anti-MMP-11 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MMP-11 purchase

MBS841071 is an antibody targeting MMP-11. Also known as MMP-11 Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for MMP-11. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Related Accession #
NCBI Official Full Name
Matrix metallopeptidase 11
NCBI Official Synonym Full Names
matrix metallopeptidase 11
NCBI Official Symbol
Mmp11
NCBI Official Synonym Symbols
ST3; SL-3; Stmy3; MMP-11
UniProt Protein Name
Stromelysin-3
UniProt Synonym Protein Names
Matrix metalloproteinase-11; MMP-11
Protein Family
UniProt Gene Name
Mmp11
UniProt Synonym Gene Names
SL-3; ST3; MMP-11
UniProt Entry Name
MMP11_MOUSE
NCBI Protein Information
stromelysin-3

NCBI Summary for MMP-11

This gene encodes a member of the matrix metalloproteinase family of endopeptidases that are involved in remodeling extracellular matrix during, for example, embryonic development and tumor progression. The encoded protein undergoes post-translational proteolytic processing by furin endopeptidase to form an active enzyme. Subcutaneous introduction of cells expressing the encoded protein into nude mice results in increased tumor incidence. Mice lacking the encoded protein exhibit a decreased incidence of chemically-induced tumors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
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UniProt Comments for MMP-11

MMP11: May play an important role in the progression of epithelial malignancies. Belongs to the peptidase M10A family.

Protein type: Protease; Secreted; Secreted, signal peptide; Extracellular matrix; EC 3.4.24.-

Cellular Component: extracellular matrix; proteinaceous extracellular matrix; extracellular region

Molecular Function: peptidase activity; zinc ion binding; metallopeptidase activity; hydrolase activity; metalloendopeptidase activity; metal ion binding; calcium ion binding

Biological Process: collagen catabolic process; extracellular matrix organization and biogenesis; collagen fibril organization; multicellular organismal development; negative regulation of fat cell differentiation; proteolysis
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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