FURIN Antibody – Rabbit Polyclonal

This gene encodes a calcium-dependent serine endoprotease that proteolytically activates different proprotein substrates traversing the secretory pathway. The encoded protein undergoes proteolytic autoactivation during which an N-terminal propeptide is cleaved to generate the mature protein. Mice lacking the encoded protein die at an embryonic stage and display hemodynamic insufficiency, cardiac ventral closure defect, axial rotation defect and abnormal yolk sac vasculature. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]

FURIN: Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif. Belongs to the peptidase S8 family. Furin subfamily.

Protein type: Membrane protein, integral; Vesicle; Protease; EC 3.4.21.75; Cell surface

Cellular Component: Golgi apparatus; extracellular space; endoplasmic reticulum membrane; Golgi cisterna; cell surface; early endosome; integral to membrane; trans-Golgi network; lipid raft; trans-Golgi network transport vesicle membrane; trans-Golgi network transport vesicle; membrane; plasma membrane

Molecular Function: serine-type endopeptidase inhibitor activity; peptidase activity; protein binding; protease binding; hydrolase activity; serine-type peptidase activity; metal ion binding; serine-type endopeptidase activity; endopeptidase activity; nerve growth factor binding; peptide binding

Biological Process: signal peptide processing; peptide hormone processing; positive regulation of transforming growth factor beta receptor signaling pathway; regulation of signal transduction; proteolysis; peptide biosynthetic process; nerve growth factor production; negative regulation of transforming growth factor-beta1 production; cell proliferation; regulation of low-density lipoprotein receptor biosynthetic process; regulation of endopeptidase activity; regulation of protein catabolic process; protein processing; negative regulation of low-density lipoprotein receptor catabolic process; secretion by cell; positive regulation of cell migration