Rabbit Anti-MBD2a Polyclonal Antibody – Cat# MBS841076

MBD2a Antibody – Rabbit Polyclonal

Name: MBD2a Antibody; Polyclonal; Rabbit; Human/Mouse/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS841076
Price: 215 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS841076

Background: The MBD family of proteins includes MeCP2, MBD1, MBD2, MBD3 and MBD4. MBD2 is highly similar to MBD3 but only MBD2 targets the MeCP1 complex to methylate DNA. MBD2 has two isoforms, MBD2a and MBD2b. MBD2a is a 414 amino acids protein, whereas… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

MBD2a, Polyclonal Antibody

Full Product Name

MBD2a Antibody

Product Gene Name

anti-MBD2a antibody

Product Synonym Names

Methyl-CpG-binding domain protein 2

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Form/Format

100 ug (0.5 mg/ml) affinity purified rabbit anti- MBD2a polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 5 mM EDTA and 0.01% thimerosal.
Appearance: Colorless liquid

Purity/Purification

Affinity purified

Concentration

0.5 mg/ml (lot specific)

Preparation and Storage

At -20 degree C
Shelf Life: 12 months

Molecular Weight

43,552 Da

3D Structure

ModBase 3D Structure for B0BNM2

Immunogen

Synthetic peptide surrounding amino acid 164 of rat MBD2a

Positive Control

Jurkat cell lysate

Handling

The antibody solution should be gently mixed before use.

Product Categories/Family for anti-MBD2a antibody

Epigenetics; MethyltransferaseAntibodies & Supporting Tools; Primary Antibodies (A-Z)

Applications Tested/Suitable for anti-MBD2a antibody

Western Blot (WB)

Application Notes for anti-MBD2a antibody

The antibody can be used in Western Blot analysis (0.5-4 ug/ml). However, the optimal concentrations should be determined individually. Blocking peptide is available separately.

Other Notes

Small volumes of anti-MBD2a antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MBD2a purchase

MBS841076 is an antibody targeting MBD2a. Also known as MBD2a Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for MBD2a. It may not necessarily be applicable to this product.

NCBI GI #

169234846

NCBI GeneID

680172

NCBI Accession #

NP_001108497.1

UniProt Primary Accession #

B0BNM2

GenBank Nucleotide #

NM_001115025.1

NCBI Official Full Name

methyl-CpG-binding domain protein 2

NCBI Official Synonym Full Names

methyl-CpG binding domain protein 2

NCBI Official Symbol

Mbd2

UniProt Protein Name

Mbd2 protein

UniProt Synonym Protein Names

Mbd2 protein

UniProt Gene Name

Mbd2

UniProt Entry Name

B0BNM2_RAT

NCBI Protein Information

methyl-CpG-binding domain protein 2

UniProt Comments for MBD2a

MBD2: Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemimethylated DNA as well. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing. May enhance the activation of some unmethylated cAMP-responsive promoters. 2 isoforms of the human protein are produced by alternative splicing.

Cellular Component: heterochromatin; protein complex; nuclear chromatin; histone deacetylase complex; cytoplasm; nucleolus; nucleus; chromatin

Molecular Function: mRNA binding; protein domain specific binding; siRNA binding; nucleosomal DNA binding; methyl-CpG binding; DNA binding; chromatin binding

Biological Process: response to nutrient levels; maternal behavior; heart development; negative regulation of transcription from RNA polymerase II promoter; response to organic cyclic substance; response to estradiol stimulus; regulation of cell proliferation; cellular protein complex assembly; response to mechanical stimulus; ATP-dependent chromatin remodeling; embryonic organ development; positive regulation of Wnt receptor signaling pathway; aging

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MBD2a antibody

Reference Product	PubMed Publications
Hdac1 antibody	>27 publications with MBD2a and Hdac1
Hdac2 antibody	>16 publications with MBD2a and Hdac2
Chd4 antibody	>7 publications with MBD2a and Chd4
Mta2 antibody	>6 publications with MBD2a and Mta2
Chd3 antibody	>4 publications with MBD2a and Chd3
Gatad2a antibody	>3 publications with MBD2a and Gatad2a
Prmt5 antibody	>2 publications with MBD2a and Prmt5
Rbbp7 antibody	>2 publications with MBD2a and Rbbp7
Chd5 antibody	>1 publications with MBD2a and Chd5

Pathways associated with anti-MBD2a antibody

Products by Pathway	Pathway Diagram
Epigenetic Regulation Of Gene Expression Pathway antibodies	Epigenetic Regulation Of Gene Expression Pathway Diagram
Gene Expression Pathway antibodies	Gene Expression Pathway Diagram
Negative Epigenetic Regulation Of RRNA Expression Pathway antibodies	Negative Epigenetic Regulation Of RRNA Expression Pathway Diagram
NoRC Negatively Regulates RRNA Expression Pathway antibodies	NoRC Negatively Regulates RRNA Expression Pathway Diagram
RNA Polymerase I Promoter Clearance Pathway antibodies	RNA Polymerase I Promoter Clearance Pathway Diagram
RNA Polymerase I Promoter Opening Pathway antibodies	RNA Polymerase I Promoter Opening Pathway Diagram
RNA Polymerase I Transcription Pathway antibodies	RNA Polymerase I Transcription Pathway Diagram
RNA Polymerase I, RNA Polymerase III, And Mitochondrial Transcription Pathway antibodies	RNA Polymerase I, RNA Polymerase III, And Mitochondrial Transcription Pathway Diagram

Diseases associated with anti-MBD2a antibody

Disease Name	Pubmed Publications
Breast Neoplasms Antibodies	>17 publications with MBD2a and Breast Neoplasms
Disease Models, Animal Antibodies	>13 publications with MBD2a and Disease Models, Animal
Lung Diseases Antibodies	>13 publications with MBD2a and Lung Diseases
Prostatic Neoplasms Antibodies	>13 publications with MBD2a and Prostatic Neoplasms
Liver Neoplasms Antibodies	>10 publications with MBD2a and Liver Neoplasms
Neurobehavioral Manifestations Antibodies	>9 publications with MBD2a and Neurobehavioral Manifestations
Liver Diseases Antibodies	>8 publications with MBD2a and Liver Diseases
Neoplasms, Experimental Antibodies	>8 publications with MBD2a and Neoplasms, Experimental
Carcinoma, Hepatocellular Antibodies	>7 publications with MBD2a and Carcinoma, Hepatocellular
Cardiovascular Diseases Antibodies	>5 publications with MBD2a and Cardiovascular Diseases

Organs/Tissues associated with anti-MBD2a antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>33 publications with MBD2a and Brain
Liver Antibodies	>25 publications with MBD2a and Liver
Lung Antibodies	>20 publications with MBD2a and Lung
Prostate Antibodies	>17 publications with MBD2a and Prostate
Kidney Antibodies	>10 publications with MBD2a and Kidney
Embryonic Tissue Antibodies	>8 publications with MBD2a and Embryonic Tissue
Muscle Antibodies	>7 publications with MBD2a and Muscle
Eye Antibodies	>5 publications with MBD2a and Eye
Spleen Antibodies	>4 publications with MBD2a and Spleen
Ovary Antibodies	>2 publications with MBD2a and Ovary