HDAC6 Antibody – Rabbit Polyclonal

HDAC6: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin. Interacts with CBFA2T3, HDAC11 and SIRT2. Interacts with F-actin. Interacts with BBIP10. Under proteasome impairment conditions, interacts with UBD via its histone deacetylase 1 and UBP-type zinc-finger regions. Interacts with CYLD. Interacts with ZMYND15. Belongs to the histone deacetylase family. HD type 2 subfamily.

Protein type: Ubiquitin conjugating system; Deacetylase; Nuclear receptor co-regulator; EC 3.5.1.98

Cellular Component: centrosome; microtubule; protein complex; leading edge; dendrite; histone deacetylase complex; perikaryon; inclusion body; caveola; cytosol; nucleoplasm; dynein complex; microtubule associated complex; cell projection; cytoplasmic microtubule; axon; perinuclear region of cytoplasm; cytoplasm; nucleus

Molecular Function: ubiquitin binding; hydrolase activity; zinc ion binding; histone deacetylase binding; metal ion binding; microtubule binding; beta-tubulin binding; beta-catenin binding; Hsp90 protein binding; misfolded protein binding; actin binding; histone deacetylase activity (H3-K9 specific); histone deacetylase activity (H3-K14 specific); protein binding; NAD-dependent histone deacetylase activity (H3-K9 specific); NAD-dependent histone deacetylase activity (H3-K14 specific); tubulin deacetylase activity; ubiquitin protein ligase binding; NAD-dependent histone deacetylase activity (H4-K16 specific); polyubiquitin binding; histone deacetylase activity; tau protein binding; alpha-tubulin binding

Biological Process: negative regulation of proteolysis; ubiquitin-dependent protein catabolic process; response to misfolded protein; protein polyubiquitination; ubiquitin-dependent protein catabolic process via the multivesicular body pathway; transcription, DNA-dependent; positive regulation of signal transduction; negative regulation of microtubule depolymerization; macroautophagy; regulation of fat cell differentiation; response to toxin; misfolded or incompletely synthesized protein catabolic process; histone deacetylation; chromatin modification; regulation of gene expression, epigenetic; response to organic substance; intracellular protein transport; protein complex disassembly; protein amino acid deacetylation; regulation of transcription, DNA-dependent; lysosome localization; regulation of receptor activity; negative regulation of protein complex disassembly