RACK1 Antibody – Rabbit Polyclonal

RACK1: a G-beta like protein containing 7 WD domains. A presumptive scaffold protein, linking protein kinase C to its substrates. Binds inositol 1,4,5-trisphosphate receptors and regulates Ca2+ release by enhancing inositol 1,4,5-trisphosphate receptor binding affinity for inositol 1,4,5-trisphosphate. An insulin-like growth factor 1 receptor-interacting protein that can regulate IGF-1-mediated Akt activation and protection from cell death.

Protein type: G protein; Motility/polarity/chemotaxis; G protein, heterotrimeric; Nuclear receptor co-regulator; Adaptor/scaffold; G protein, heterotrimeric beta

Chromosomal Location of Human Ortholog: 5q35.3

Cellular Component: small ribosomal subunit; cytoskeleton; mitochondrion; cell soma; perinuclear region of cytoplasm; dendrite; cytoplasm; perikaryon; midbody; nucleus; cytosol; phagocytic cup

Molecular Function: protein tyrosine kinase inhibitor activity; protein binding; protein homodimerization activity; enzyme binding; protein kinase C binding; caspase activator activity; SH2 domain binding; protein complex scaffold; receptor tyrosine kinase binding; protein phosphatase binding; ion channel inhibitor activity; receptor binding

Biological Process: caspase activation; negative regulation of phagocytosis; negative regulation of protein kinase B signaling cascade; negative regulation of Wnt receptor signaling pathway; viral reproduction; regulation of cell cycle; positive regulation of protein homooligomerization; positive regulation of apoptosis; rhythmic process; gastrulation; cell cycle; osteoblast differentiation; regulation of protein localization; positive regulation of mitochondrial depolarization; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; negative regulation of translation; positive regulation of cAMP catabolic process; positive regulation of cyclic-nucleotide phosphodiesterase activity; positive regulation of protein amino acid phosphorylation; negative regulation of cell growth; regulation of cell division; positive regulation of GTPase activity; positive regulation of cell migration