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DR5 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS841137

Background: DR5 is the DD containing receptor for TRAIL, Apo2, TRAIL-R2, TRICK2, or KILLER. DR5 transcript is widely expressed in normal tissues and in many types of tumor cells. Like DR3 and TNFR1, DR5 mediate apoptosis by FADD dependent pathway.… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
DR5, Polyclonal Antibody
Full Product Name
DR5 Antibody
Product Gene Name
Product Synonym Names
TNFRSF10B; TRICKB,TRANCE-R; ZTNFR9; CD262; TRICK2A; Apo2; TRAIL-R2; TRICK2; KILLER
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
100 ug (0.2 mg/ml) immunoaffinity purified rabbit anti-DR5 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.
Appearance: Colorless liquid
Purity/Purification
Affinity purified
Concentration
0.2 mg/ml (lot specific)
Preparation and Storage
At -20 degree C
Shelf Life: 12 months
Molecular Weight
42,165 Da
3D Structure
ModBase 3D Structure for Q9QZM4
Immunogen
Synthetic peptide corresponding to residues surrounding amino acid 372 of mouse DR5 precursor
Handling
The antibody solution should be gently mixed before use.
Applications Tested/Suitable for anti-DR5 antibody
Western Blot (WB)
Application Notes for anti-DR5 antibody
Western blot analysis (0.5-4 ug/ml). However, the optimal conditions should be determined individually. The antibody detects 60 kDa DR5 in samples of human and mouse origins

Testing Data of anti-DR5 antibody

Rabbit Anti-DR5 Polyclonal Antibody – Cat# MBS841137

Other Notes

Small volumes of anti-DR5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DR5 purchase

MBS841137 is an antibody targeting DR5. Also known as DR5 Antibody. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for DR5. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
tumor necrosis factor receptor superfamily member 10B
NCBI Official Synonym Full Names
tumor necrosis factor receptor superfamily, member 10b
NCBI Official Symbol
Tnfrsf10b
NCBI Official Synonym Symbols
MK; DR5; Ly98; KILLER; TRICKB; TRAILR2; TRICK2A; TRICK2B
UniProt Protein Name
Tumor necrosis factor receptor superfamily member 10B
UniProt Synonym Protein Names
Death receptor 5; MK; CD_antigen: CD262
UniProt Gene Name
Tnfrsf10b
UniProt Synonym Gene Names
Dr5; Killer
UniProt Entry Name
TR10B_MOUSE
NCBI Protein Information
tumor necrosis factor receptor superfamily member 10B

UniProt Comments for DR5

TRAIL-R1: Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF- kappa-B.

Protein type: Membrane protein, integral

Cellular Component: membrane; integral to membrane

Molecular Function: protease binding; TRAIL binding; caspase activator activity; transcription factor binding

Biological Process: caspase activation; regulation of apoptosis; induction of apoptosis via death domain receptors; apoptosis; signal transduction
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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