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NATL/LAB Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS841201

Background: Non-T cell Activation Linker (NTAL) is also known as linker for activation of B cells (LAB), is a transmembrane adaptor protein. NTAL is expressed in B cells, mast cells, monocytes and NK cells. When NTAL is tyrosine phosphorylated, it recruits… More details

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Testing Data View PDF
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Product Overview

Product Name
NATL/LAB, Polyclonal Antibody
Full Product Name
NATL / LAB Antibody
Product Gene Name
Product Synonym Names
HSPC046; LAB; LAT2; NTAL; WBSCR15; WBSCR5; WSCR5
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Rat
Form/Format
100 ug (0.5 mg/ml) affinity purified rabbit polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.
Appearance: Colorless liquid
Purity/Purification
Affinity purified
Concentration
0.5 mg/ml (lot specific)
Preparation and Storage
At -20 degree C
Shelf Life: 12 months
Molecular Weight
23,130 Da
3D Structure
ModBase 3D Structure for Q8CGL2
Immunogen
Synthetic peptide surrounding amino acid 187 of rat NTAL
Handling
The antibody solution should be gently mixed before use.
Applications Tested/Suitable for anti-NATL/LAB antibody
Western Blot (WB)
Application Notes for anti-NATL/LAB antibody
Western blotting (0.5-4 ug/ml). However, the optimal conditions should be determined individually. The antibody detects a 22 kDa rat NTAL/LAB. Other species have not been determined.

Testing Data of anti-NATL/LAB antibody

Rabbit Anti-NATL/LAB Polyclonal Antibody – Cat# MBS841201

Other Notes

Small volumes of anti-NATL/LAB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NATL/LAB purchase

MBS841201 is an antibody targeting NATL/LAB. Also known as NATL / LAB Antibody. Reactive in Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for NATL/LAB. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
linker for activation of T-cells family member 2
NCBI Official Synonym Full Names
linker for activation of T cells family, member 2
NCBI Official Symbol
Lat2
NCBI Official Synonym Symbols
Ntal; Wbscr5
UniProt Protein Name
Linker for activation of T-cells family member 2
UniProt Synonym Protein Names
Linker for activation of B-cells; Non-T-cell activation linker
UniProt Gene Name
Lat2
UniProt Synonym Gene Names
Lab; Ntal; Wbscr5
UniProt Entry Name
NTAL_RAT
NCBI Protein Information
linker for activation of T-cells family member 2

NCBI Summary for NATL/LAB

human homolog maps to the microdeletion region in Williams syndrome and may act as an adaptor for non T-cell immune response [RGD, Feb 2006]

UniProt Comments for NATL/LAB

LAB: linker for activation of B cells (LAB) is an adaptor protein. B cell antigen receptor signaling leads to its phosphorylation and interaction with the adaptor protein Grb2. Decreased expression leads to a reduction in BCR-mediated calcium flux and Erk activation. Localized to lipid rafts.

Protein type: Adaptor/scaffold; Membrane protein, integral

Cellular Component: mast cell granule; plasma membrane; integral to membrane; lipid raft

Molecular Function: SH2 domain binding

Biological Process: B cell receptor signaling pathway; B cell activation; calcium-mediated signaling; mast cell degranulation
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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