Rabbit Anti-PSGL-1 Polyclonal Antibody – Cat# MBS841264

PSGL-1 Antibody – Rabbit Polyclonal

Name: PSGL-1 Antibody; Polyclonal; Rabbit; Human/Mouse/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS841264
Price: 215 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS841264

Polyclonal Antibody to detect PSGL-1 in human, mouse and rat samplesBackground: PSGL-1 (P-Selectin glycoprotein ligand, also designated CD162), exists as a disulfide-linked homodimer. PSGL-1 is a type 1 membrane protein that localizes on the tips of… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

PSGL-1, Polyclonal Antibody

Full Product Name

PSGL-1 Antibody

Product Gene Name

anti-PSGL-1 antibody

Product Synonym Names

PSGL; CD162; SELPLG; CLA; CD162; PSGL1; Selectin P ligand.

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Form/Format

100 ug (0.5 mg/ml) of antibody in PBS pH 7.2 containing 0.01 % BSA, 0.01 % thimerosal, and 50 % glycerol.
Appearance: Colorless liquid

Purity/Purification

Affinity Purified Antibody

Concentration

0.5 mg/ml (lot specific)

Preparation and Storage

At -20 degree C
Shelf Life: 12 months

Molecular Weight

44,648 Da

OMIM

600738

3D Structure

ModBase 3D Structure for Q14242

Immunogen

Synthetic peptide near C-terminal (BV-L31-32)

Positive Control

Western blot: Jurkat Cell lysate

Handling

The antibody solution should be gently mixed before use.

Product Categories/Family for anti-PSGL-1 antibody

Antibodies & Supporting Tools; Primary Antibodies (A-Z)

Applications Tested/Suitable for anti-PSGL-1 antibody

Western Blot (WB)

Application Notes for anti-PSGL-1 antibody

Western blot: 1-4 ug/ml.

Other Notes

Small volumes of anti-PSGL-1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PSGL-1 purchase

MBS841264 is an antibody targeting PSGL-1. Also known as PSGL-1 Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PSGL-1. It may not necessarily be applicable to this product.

NCBI GI #

331284238

NCBI GeneID

6404

NCBI Accession #

NP_001193538.1

UniProt Primary Accession #

Q14242

UniProt Secondary Accession #

Q12775; Q6GTW7; Q8N7J7; A8K2Y0; B4DQC3; B7Z5C7; J3KMX6

UniProt Related Accession #

Q14242

GenBank Nucleotide #

NM_001206609.1

NCBI Official Full Name

P-selectin glycoprotein ligand 1 isoform 1

NCBI Official Synonym Full Names

selectin P ligand

NCBI Official Symbol

SELPLG

NCBI Official Synonym Symbols

CLA; CD162; PSGL1; PSGL-1

UniProt Protein Name

P-selectin glycoprotein ligand 1

UniProt Synonym Protein Names

Selectin P ligand; CD_antigen: CD162

Protein Family

P-selectin glycoprotein ligand

UniProt Gene Name

SELPLG

UniProt Synonym Gene Names

PSGL-1

UniProt Entry Name

SELPL_HUMAN

NCBI Protein Information

P-selectin glycoprotein ligand 1

NCBI Summary for PSGL-1

This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2011]

UniProt Comments for PSGL-1

SELPLG: A SLe(x)-type glycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. PSGL1 is critical for the initial leukocyte capture.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 12q24

Cellular Component: membrane; integral to plasma membrane; integral to membrane; plasma membrane

Molecular Function: protein binding; receptor binding

Biological Process: leukocyte tethering or rolling; cell adhesion; blood coagulation; leukocyte adhesive activation; leukocyte migration

Research Articles on PSGL-1

1. expression of P-selectin and P-selectin glycoprotein ligand-1, forming an auto-augmented loop of porcine aortic endothelial cells and platelet activation

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PSGL-1 antibody

Reference Product	PubMed Publications
SELP antibody	>7 publications with PSGL-1 and SELP
SELL antibody	>2 publications with PSGL-1 and SELL

Diseases associated with anti-PSGL-1 antibody

Disease Name	Pubmed Publications
Cardiovascular Diseases Antibodies	>8 publications with PSGL-1 and Cardiovascular Diseases
Atherosclerosis Antibodies	>4 publications with PSGL-1 and Atherosclerosis
Inflammation Antibodies	>2 publications with PSGL-1 and Inflammation
Diabetes Mellitus, Type 2 Antibodies	>1 publications with PSGL-1 and Diabetes Mellitus, Type 2
Neurobehavioral Manifestations Antibodies	>1 publications with PSGL-1 and Neurobehavioral Manifestations
Myocardial Infarction Antibodies	>1 publications with PSGL-1 and Myocardial Infarction
Neoplasms, Experimental Antibodies	>1 publications with PSGL-1 and Neoplasms, Experimental
Necrosis Antibodies	>1 publications with PSGL-1 and Necrosis

Organs/Tissues associated with anti-PSGL-1 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>12 publications with PSGL-1 and Blood
Bone Antibodies	>2 publications with PSGL-1 and Bone
Heart Antibodies	>2 publications with PSGL-1 and Heart
Bone Marrow Antibodies	>2 publications with PSGL-1 and Bone Marrow
Placenta Antibodies	>2 publications with PSGL-1 and Placenta
Embryonic Tissue Antibodies	>2 publications with PSGL-1 and Embryonic Tissue
Uterus Antibodies	>1 publications with PSGL-1 and Uterus
Lung Antibodies	>1 publications with PSGL-1 and Lung
Spleen Antibodies	>1 publications with PSGL-1 and Spleen
Brain Antibodies	>1 publications with PSGL-1 and Brain