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JMJD2b Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS841286

Polyclonal Antibody to detect JMJD2b in human samples. Background: JMJD2b belongs to the JMJD2 family of histone demethylases which play an important role in the establishment of the histone code. JMJD2b specifically demethylates the trimethylated K9 of… More details

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Testing Data View PDF
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Product Overview

Product Name
JMJD2b, Polyclonal Antibody
Full Product Name
JMJD2b polyclonal antibody
Product Gene Name
anti-JMJD2b antibody
Product Synonym Names
JHDM3b; KDM4b
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
In PBS with 0.05% (W/V) sodium azide.
Appearance: Colorless liquid
Preparation and Storage
At -20 degree C
Shelf Life: 12 months
Molecular Weight
50,582 Da
OMIM
609765
3D Structure
ModBase 3D Structure for O94953
Immunogen
Polyclonal antibody raised in rabbit against human JMJD2b (Jumonji Domain containing 2b), using a KLH-conjugated synthetic peptide containing an amino acid sequence from the central part of the protein.
Positive Control
Western blot: HeLa cells, ELISA: Peptides, IF: HeLa cells.
Handling
The antibody solution should be gently mixed before use.

Product Categories/Family for anti-JMJD2b antibody

Epigenetics; Eraser Enzymes; Histone Demethylases (HDMs); Antibodies & Blocking PeptdiesAntibodies & Supporting Tools; Antibodies for Epigenetics ResearchAntibodies & Supporting Tools; Primary Antibodies (A-Z)
Applications Tested/Suitable for anti-JMJD2b antibody
Western Blot (WB), ELISA (EIA), Immunofluorescence (IF)
Application Notes for anti-JMJD2b antibody
Western Blot: 1:1000, ELISA: 1:200, IF: 1:200.

Testing Data of anti-JMJD2b antibody

Rabbit Anti-JMJD2b Polyclonal Antibody – Cat# MBS841286

Other Notes

Small volumes of anti-JMJD2b antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for JMJD2b purchase

MBS841286 is an antibody targeting JMJD2b. Also known as JMJD2b polyclonal antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for JMJD2b. It may not necessarily be applicable to this product.

NCBI GI #
45504380
NCBI GeneID
23030
NCBI Accession #
NP_055830.1
UniProt Primary Accession #
O94953
UniProt Secondary Accession #
O75274; Q6P3R5; Q9P1V1; Q9UF40; B9EGN8; D6W631
UniProt Related Accession #
O94953
GenBank Nucleotide #
NM_015015.2
NCBI Official Full Name
lysine-specific demethylase 4B
NCBI Official Synonym Full Names
lysine (K)-specific demethylase 4B
NCBI Official Symbol
KDM4B
NCBI Official Synonym Symbols
JMJD2B; TDRD14B
UniProt Protein Name
Lysine-specific demethylase 4B
UniProt Synonym Protein Names
JmjC domain-containing histone demethylation protein 3B; Jumonji domain-containing protein 2B
UniProt Gene Name
KDM4B
UniProt Synonym Gene Names
JHDM3B; JMJD2B; KIAA0876
UniProt Entry Name
KDM4B_HUMAN
NCBI Protein Information
lysine-specific demethylase 4B

UniProt Comments for JMJD2b

JMJD2B: Histone demethylase that specifically demethylates 'Lys- 9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate. Belongs to the JHDM3 histone demethylase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Oxidoreductase; Demethylase; EC 1.14.11.-

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: nucleoplasm; focal adhesion; nucleus; cell junction

Molecular Function: dioxygenase activity; zinc ion binding

Biological Process: establishment and/or maintenance of chromatin architecture; regulation of transcription, DNA-dependent; transcription, DNA-dependent; chromatin modification
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Research Articles on JMJD2b

1. Functional studies demonstrated that KDM4B regulates the Myc pathway. N-Myc was found to physically interact with and recruit KDM4B. KDM4B was found to regulate neuroblastoma cell proliferation and differentiation in vitro and xenograft growth in vivo.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-JMJD2b antibody

 Reference Product  PubMed Publications
 KDM3A antibody  >4 publications with JMJD2b and KDM3A
 CCND1 antibody  >3 publications with JMJD2b and CCND1
 CCNA1 antibody  >2 publications with JMJD2b and CCNA1
 JMJD1C antibody  >1 publications with JMJD2b and JMJD1C
 MLL2 antibody  >1 publications with JMJD2b and MLL2

Pathways associated with anti-JMJD2b antibody

 Products by Pathway  Pathway Diagram
 Chromatin Modifying Enzymes Pathway antibodies  Chromatin Modifying Enzymes Pathway Diagram
 Chromatin Organization Pathway antibodies  Chromatin Organization Pathway Diagram
 HDMs Demethylate Histones Pathway antibodies  HDMs Demethylate Histones Pathway Diagram

Diseases associated with anti-JMJD2b antibody

 Disease Name  Pubmed Publications
 Gastrointestinal Diseases Antibodies  >7 publications with JMJD2b and Gastrointestinal Diseases
 Breast Neoplasms Antibodies  >6 publications with JMJD2b and Breast Neoplasms
 Leukemia Antibodies  >3 publications with JMJD2b and Leukemia
 Neoplasms, Experimental Antibodies  >3 publications with JMJD2b and Neoplasms, Experimental
 Lung Neoplasms Antibodies  >2 publications with JMJD2b and Lung Neoplasms
 Alopecia Antibodies  >1 publications with JMJD2b and Alopecia
 Immune System Diseases Antibodies  >1 publications with JMJD2b and Immune System Diseases
 Multiple Myeloma Antibodies  >1 publications with JMJD2b and Multiple Myeloma
 Cardiovascular Diseases Antibodies  >1 publications with JMJD2b and Cardiovascular Diseases
 Neoplasm Metastasis Antibodies  >1 publications with JMJD2b and Neoplasm Metastasis

Organs/Tissues associated with anti-JMJD2b antibody

 Organ/Tissue Name  Pubmed Publications
 Prostate Antibodies  >6 publications with JMJD2b and Prostate
 Stomach Antibodies  >3 publications with JMJD2b and Stomach
 Lung Antibodies  >2 publications with JMJD2b and Lung
 Blood Antibodies  >2 publications with JMJD2b and Blood
 Bone Antibodies  >2 publications with JMJD2b and Bone
 Lymph Node Antibodies  >1 publications with JMJD2b and Lymph Node
 Kidney Antibodies  >1 publications with JMJD2b and Kidney
 Intestine Antibodies  >1 publications with JMJD2b and Intestine
 Eye Antibodies  >1 publications with JMJD2b and Eye
 Testis Antibodies  >1 publications with JMJD2b and Testis
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