LKB1 Antibody – Rabbit Polyclonal

This gene encodes a member of the serine/threonine kinase family. The encoded protein, a known tumor suppressor, activates (via phosphorylation) adenine monophosphate-activated protein kinase (AMPK) and AMPK-related kinase proteins. This upstream regulation of the AMPK pathway is thought to regulate a number of different processes, including cell metabolism, cell polarity, apoptosis and DNA damage response. Mutations in a similar gene in human have been associated with Peutz-Jeghers syndrome. Alternative splicing results in multiple transcript variants, including the S isoform which plays a potential role in spermiogenesis. [provided by RefSeq, Sep 2014]

LKB1: a S/T protein kinase of the CAMKL family. A tumor suppressor that helps control cell structure, polarity, apoptosis and energy homeostasis. Phosphorylates AGS3 (activator of G-protein signaling 3) GPR domains, regulating the interaction of GPR-containing proteins with G-proteins. A cytosolic protein complex comprised of LKB1, the pseudokinase STRAD, and the MO25 scaffold protein. Activates AMPK and several related protein kinases. AMPK plays a predominant role as the master regulator of cellular energy homeostasis, controlling downstream effectors that regulate cell growth and apoptosis in response to cellular ATP concentrations. The Lkb1/Strad/Mo25 complex can polarize single epithelial cells, leading to the formation of a brush border containing microvilli on the apical surface. Mutation in the corresponding gene causes Peutz-Jeghers syndrome (PJS), an autosomal dominant disorder characterized by benign GI tract polyps and dark skin lesions of the mouth, hands and feet. A variety of other LKB1 gene mutations have been associated with the formation of sporadic cancers in several tissues.

Protein type: Tumor suppressor; Autophagy; Kinase, protein; EC 2.7.11.1; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); CAMK group; CAMKL family; LKB subfamily

Cellular Component: protein complex; membrane; mitochondrion; cytoplasm; nucleus; cytosol

Molecular Function: p53 binding; metal ion binding; magnesium ion binding; nucleotide binding; LRR domain binding; protein kinase activity; transferase activity; protein serine/threonine kinase activity; protein binding; transferase activity, transferring phosphorus-containing groups; protein complex binding; kinase activity; protein kinase activator activity; ATP binding

Biological Process: Golgi localization; protein heterooligomerization; apoptosis; regulation of dendrite morphogenesis; protein amino acid autophosphorylation; Wnt receptor signaling pathway through beta-catenin; glucose homeostasis; response to lipid; protein amino acid phosphorylation; T cell receptor signaling pathway; anoikis; negative regulation of cell proliferation; positive regulation of gluconeogenesis; vasculature development; tissue homeostasis; regulation of cell growth; cell cycle arrest; cell differentiation; positive thymic T cell selection; regulation of Wnt receptor signaling pathway; positive regulation of transforming growth factor beta receptor signaling pathway; regulation of protein kinase B signaling cascade; cell cycle; positive regulation of peptidyl-tyrosine phosphorylation; axonogenesis; establishment of cell polarity; positive regulation of protein kinase activity; activation of protein kinase activity; autophagy; spermatogenesis; positive regulation of axonogenesis; response to ionizing radiation; negative regulation of cell growth; phosphorylation; response to DNA damage stimulus; spermatid development