Rabbit Anti-HK3 Polyclonal Antibody – Cat# MBS841296

HK3 Antibody – Rabbit Polyclonal

Name: HK3 Antibody; Polyclonal; Rabbit; Human/Mouse-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS841296
Price: 460 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS841296

Background: Hexokinases phosphorylate glucose to produce glucose-6-phosphate, thus committing glucose to the glycolytic pathway. This gene encodes hexokinase 3. Similar to hexokinases 1 and 2, this allosteric enzyme is inhibited by its product… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

HK3 (Hexokinase III), Polyclonal Antibody

Full Product Name

HK3 (Hexokinase III) (CT) Antibody

Product Gene Name

anti-HK3 antibody

Product Synonym Names

Hexokinase type III; HK III

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human, Mouse

Form/Format

100 ug (0.25 mg/ml) purified rabbit Ig polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
Appearance: Colorless liquid

Purity/Purification

Affinity purified

Concentration

0.25 mg/ml (lot specific)

Preparation and Storage

At -20 degree C
Shelf Life: 12 months

Molecular Weight

99,025 Da

OMIM

142570

3D Structure

ModBase 3D Structure for P52790

Immunogen

Synthetic peptide from the 767 to 797 amino acids of the C-terminal region of human HK3.

Positive Control

Western Blot: HL-60 cell lysate and mouse brain tissue lysate Immunohistochemistry: Human Hepatocarcinoma tissue

Handling

The antibody solution should be gently mixed before use.

Applications Tested/Suitable for anti-HK3 antibody

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

Application Notes for anti-HK3 antibody

The antibody can be used for ELISA (1:1000), Western Blotting (1:100 - 1:500), IHC (1:50 - 1:100).

Other Notes

Small volumes of anti-HK3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for HK3 purchase

MBS841296 is an antibody targeting HK3. Also known as HK3 (Hexokinase III) (CT) Antibody. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for HK3. It may not necessarily be applicable to this product.

NCBI GI #

194097330

NCBI GeneID

3101

NCBI Accession #

NP_002106.2

UniProt Primary Accession #

P52790

UniProt Secondary Accession #

Q8N1E7

UniProt Related Accession #

P52790

GenBank Nucleotide #

NM_002115.2

NCBI Official Full Name

hexokinase-3

NCBI Official Synonym Full Names

hexokinase 3 (white cell)

NCBI Official Symbol

HK3

NCBI Official Synonym Symbols

HXK3; HKIII

UniProt Protein Name

Hexokinase-3

UniProt Synonym Protein Names

Hexokinase type III; HK III

Protein Family

Probable histidine kinase

UniProt Gene Name

HK3

UniProt Synonym Gene Names

HK III

UniProt Entry Name

HXK3_HUMAN

NCBI Protein Information

hexokinase-3

NCBI Summary for HK3

Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase 3. Similar to hexokinases 1 and 2, this allosteric enzyme is inhibited by its product glucose-6-phosphate. [provided by RefSeq, Apr 2009]

UniProt Comments for HK3

HK3: a glycolytic enzyme that catalyzes the reaction ATP + D-hexose = ADP + D-hexose 6-phosphate. The first and rate-limiting step in glycosis, a pathway that produces energy in the form of ATP from glucose. An allosteric enzyme inhibited by its product glucose-6-phosphate (Glc-6-P). Acts as a ""glucose sensor"" by trapping glucose inside the cell by catalyzing its phosphorylation to produce Glc-6-P. In vertebrates there are four major glucose-phosphorylating isoenzymes, designated hexokinase I, II, III and IV (glucokinase).

Protein type: Carbohydrate Metabolism - fructose and mannose; Kinase, other; Enzyme, cellular metabolism; Carbohydrate Metabolism - galactose; EC 2.7.1.1; Carbohydrate Metabolism - amino sugar and nucleotide sugar; Transferase; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - starch and sucrose

Chromosomal Location of Human Ortholog: 5q35.2

Cellular Component: protein complex; mitochondrion; cytosol

Molecular Function: hexokinase activity; enzyme binding; hormone binding; mannokinase activity; fructokinase activity; glucokinase activity; ATP binding

Biological Process: hexose metabolic process; glycolysis; hexose transport; carbohydrate metabolic process; glucose 6-phosphate metabolic process; carbohydrate phosphorylation; cell glucose homeostasis; pathogenesis; glucose transport; transmembrane transport

Research Articles on HK3

1. Through glycolysis and arachidonic acid metabolism, HK3 and PTGS2 might play important roles in pediatric ALL and its prognosis, and thus, might be potential targets for therapeutic intervention to suppress pediatric ALL.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-HK3 antibody

Reference Product	PubMed Publications
PFKFB2 antibody	>1 publications with HK3 and PFKFB2

Pathways associated with anti-HK3 antibody

Products by Pathway	Pathway Diagram
Amino Sugar And Nucleotide Sugar Metabolism Pathway antibodies	Amino Sugar And Nucleotide Sugar Metabolism Pathway Diagram
Amino Sugar And Nucleotide Sugar Metabolism Pathway antibodies	Amino Sugar And Nucleotide Sugar Metabolism Pathway Diagram
Biosynthesis Of Antibiotics Pathway antibodies	Biosynthesis Of Antibiotics Pathway Diagram
Butirosin And Neomycin Biosynthesis Pathway antibodies	Butirosin And Neomycin Biosynthesis Pathway Diagram
Butirosin And Neomycin Biosynthesis Pathway antibodies	Butirosin And Neomycin Biosynthesis Pathway Diagram
Carbohydrate Digestion And Absorption Pathway antibodies	Carbohydrate Digestion And Absorption Pathway Diagram
Carbohydrate Digestion And Absorption Pathway antibodies	Carbohydrate Digestion And Absorption Pathway Diagram
Carbon Metabolism Pathway antibodies	Carbon Metabolism Pathway Diagram
Carbon Metabolism Pathway antibodies	Carbon Metabolism Pathway Diagram
Central Carbon Metabolism In Cancer Pathway antibodies	Central Carbon Metabolism In Cancer Pathway Diagram

Diseases associated with anti-HK3 antibody

Disease Name	Pubmed Publications
Ovarian Neoplasms Antibodies	>12 publications with HK3 and Ovarian Neoplasms
Carcinoma Antibodies	>10 publications with HK3 and Carcinoma
Hyperplasia Antibodies	>8 publications with HK3 and Hyperplasia
Carcinoma, Hepatocellular Antibodies	>2 publications with HK3 and Carcinoma, Hepatocellular
Liver Neoplasms Antibodies	>2 publications with HK3 and Liver Neoplasms
Liver Diseases Antibodies	>2 publications with HK3 and Liver Diseases
Neoplasms, Experimental Antibodies	>1 publications with HK3 and Neoplasms, Experimental
Cell Transformation, Neoplastic Antibodies	>1 publications with HK3 and Cell Transformation, Neoplastic
Lung Neoplasms Antibodies	>1 publications with HK3 and Lung Neoplasms
Inflammation Antibodies	>1 publications with HK3 and Inflammation

Organs/Tissues associated with anti-HK3 antibody

Organ/Tissue Name	Pubmed Publications
Prostate Antibodies	>54 publications with HK3 and Prostate
Blood Antibodies	>24 publications with HK3 and Blood
Brain Antibodies	>5 publications with HK3 and Brain
Skin Antibodies	>5 publications with HK3 and Skin
Testis Antibodies	>5 publications with HK3 and Testis
Lung Antibodies	>3 publications with HK3 and Lung
Muscle Antibodies	>2 publications with HK3 and Muscle
Connective Tissue Antibodies	>1 publications with HK3 and Connective Tissue