FOXP3 Antibody – Rabbit Polyclonal

FOXP3: Probable transcription factor. Plays a critical role in the control of immune response. Interacts with IKZF3. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Transcription factor; Cell cycle regulation; C2H2-type zinc finger protein

Cellular Component: cytoplasm; intracellular; nucleus

Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; histone acetyltransferase binding; protein binding; protein homodimerization activity; NFAT protein binding; nucleic acid binding; DNA binding; sequence-specific DNA binding; histone deacetylase binding; metal ion binding; transcription corepressor activity; transcription factor activity

Biological Process: negative regulation of interleukin-10 production; positive regulation of transcription, DNA-dependent; regulation of immunoglobulin production; myeloid cell homeostasis; negative regulation of cytokine secretion; T cell receptor signaling pathway; negative regulation of interleukin-2 production; negative regulation of interleukin-6 production; tolerance induction to self antigen; positive regulation of T cell tolerance induction; regulatory T cell differentiation; positive regulation of regulatory T cell differentiation; transcription, DNA-dependent; negative regulation of transcription factor activity; negative regulation of immune response; cytokine production; negative regulation of T cell cytokine production; positive regulation of peripheral T cell tolerance induction; regulation of transcription from RNA polymerase II promoter; inhibition of NF-kappaB transcription factor; regulation of T cell anergy; negative regulation of interleukin-5 production; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; inhibition of CREB transcription factor; negative regulation of cytokine biosynthetic process; transcription from RNA polymerase II promoter; negative regulation of interleukin-4 production; T cell activation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of interferon-gamma biosynthetic process; negative regulation of histone acetylation; negative regulation of lymphocyte proliferation; positive regulation of interleukin-4 production; negative regulation of cell proliferation; negative regulation of isotype switching to IgE isotypes; CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment; negative regulation of T cell proliferation; regulation of transcription, DNA-dependent; B cell homeostasis; negative regulation of interferon-gamma production; regulation of isotype switching to IgG isotypes; positive regulation of T cell anergy; CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation; positive regulation of transforming growth factor-beta1 production; negative regulation of chronic inflammatory response; negative regulation of histone deacetylation; T cell mediated immunity; positive regulation of immature T cell proliferation in the thymus; negative regulation of tumor necrosis factor production; tolerance induction; negative regulation of interleukin-17 production; positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation; negative regulation of inflammatory response; negative regulation of interleukin-2 biosynthetic process; positive regulation of histone acetylation