TPR Antibody – Rabbit Polyclonal

This gene encodes a large coiled-coil protein that forms intranuclear filaments attached to the inner surface of nuclear pore complexes (NPCs). The protein directly interacts with several components of the NPC. It is required for the nuclear export of mRNAs and some proteins. Oncogenic fusions of the 5' end of this gene with several different kinase genes occur in some neoplasias. [provided by RefSeq, Jul 2008]

TPR: a large coiled-coil nuclear pore protein that forms filamentous structures extending from nuclear pore complexes (NPCs) into the perinucleolar region. Together with Lamina-associated polypeptide 2 (LAP2) family members and Nup153, forms structural links between the nuclear lamina and the internal nuclear matrix. In interphase, localizes to the nucleoplasmic side of the nuclear pore complex (NPC) core structure, forming a fibrous structure called the nuclear basket. Essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus. Involved in the formation and/or maintenance of NPC-associated perinuclear heterochromatin exclusion zones (HEZs). Implicated in nuclear export of mRNAs transcribed from heat shock gene promoters; associates both with chromatin in the HSP70 promoter and with mRNAs transcribed from this promoter under stress-induced conditions. Translocations between human TPR and TrkA, MET, and RAF genes are oncogenic. Its N-terminus is involved in activation of oncogenic kinases.

Protein type: Nuclear envelope; Membrane protein, peripheral; Nucleoporin; Oncoprotein

Chromosomal Location of Human Ortholog: 1q25

Cellular Component: nucleoplasm; kinetochore; nuclear membrane; extrinsic to membrane; cytoplasmic dynein complex; cytoplasm; nuclear envelope; nuclear pore; nucleus; nuclear inclusion body

Molecular Function: mRNA binding; tubulin binding; protein binding; protein homodimerization activity; transporter activity; protein anchor; heat shock protein binding; mitogen-activated protein kinase binding; chromatin binding; nucleocytoplasmic transporter activity

Biological Process: nuclear pore complex assembly; negative regulation of translational initiation; viral reproduction; positive regulation of heterochromatin formation; RNA export from nucleus; mitotic nuclear envelope disassembly; nuclear matrix organization and biogenesis; regulation of protein stability; pathogenesis; viral infectious cycle; glucose transport; negative regulation of transcription from RNA polymerase II promoter; RNA import into nucleus; regulation of protein export from nucleus; positive regulation of protein export from nucleus; regulation of protein import into nucleus; nuclear pore organization and biogenesis; protein import into nucleus; mitotic cell cycle spindle assembly checkpoint; viral transcription; protein export from nucleus; transmembrane transport; mitosis; cytokine and chemokine mediated signaling pathway; negative regulation of RNA export from nucleus; nuclear translocation of MAPK; mRNA export from nucleus during heat stress; positive regulation of protein import into nucleus; cell division; hexose transport; carbohydrate metabolic process; gene expression; mitotic cell cycle