Rabbit Anti-MMP-13 Polyclonal Antibody – Cat# MBS841402

MMP-13 Antibody – Rabbit Polyclonal

Name: MMP-13 Antibody; Polyclonal; Rabbit; MyBioSource
Brand: MyBioSource
SKU: MBS841402
Price: 215 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS841402

Background: The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, fibronectin, laminin and proteoglycan. Transcription of MMP genes is… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

MMP-13, Polyclonal Antibody

Full Product Name

MMP-13 Antibody

Product Gene Name

anti-MMP-13 antibody

Product Synonym Names

MMP13; CLG3; Collagenase 3; Matrix metalloproteinase 13

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human, Mouse, Rat, Horse, Bovine

Form/Format

100 ug (0.5 mg/ml) affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.
Appearance: Colorless liquid

Purity/Purification

Affinity purified

Concentration

0.5 mg/ml (lot specific)

Preparation and Storage

At -20 degree C
Shelf Life: 12 months

Molecular Weight

53,375 Da

3D Structure

ModBase 3D Structure for P23097

Immunogen

Synthetic peptide surrounding amino acid 454 of rat MMP-13

Handling

The antibody solution should be gently mixed before use.

Applications Tested/Suitable for anti-MMP-13 antibody

Western Blot (WB), Immunoprecipitation (IP), Immunofluorescence (IF), Immunohistochemistry (IHC)

Application Notes for anti-MMP-13 antibody

Western blotting (0.5-4 ug/ml), immunoprecipitation and Immunohistochemistry (works with paraffin imbedded sections). However, the optimal concentrations should be determined individually. The antibody recognizes the proenzyme (~60 kDa) and the cleaved fragments (34 kDa and 48 kDa) of MMP-13. Reactivity to other species has not been tested.

Other Notes

Small volumes of anti-MMP-13 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MMP-13 purchase

MBS841402 is an antibody targeting MMP-13. Also known as MMP-13 Antibody. Reactive in Human, Mouse, Rat, Horse, Bovine. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for MMP-13. It may not necessarily be applicable to this product.

NCBI GI #

116872

NCBI GeneID

171052

NCBI Accession #

P23097.1

UniProt Primary Accession #

P23097

UniProt Related Accession #

P23097

NCBI Official Full Name

Collagenase 3

NCBI Official Synonym Full Names

matrix metallopeptidase 13

NCBI Official Symbol

Mmp13

UniProt Protein Name

Collagenase 3

UniProt Synonym Protein Names

Matrix metalloproteinase-13; MMP-13; UMRCASE

Protein Family

Collagenase

UniProt Gene Name

Mmp13

UniProt Synonym Gene Names

MMP-13

UniProt Entry Name

MMP13_RAT

NCBI Protein Information

collagenase 3

NCBI Summary for MMP-13

enzyme that degrades collagen type I [RGD, Feb 2006]

UniProt Comments for MMP-13

Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CTGF. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bone development and ossification. Plays a role in the healing of bone fractures via endochondral ossification. Plays a role in wound healing, probably by a mechanism that involves proteolytic activation of TGFB1 and degradation of CTGF. Plays a role in keratinocyte migration during wound healing. May play a role in cell migration and in tumor cell invasion ().

Research Articles on MMP-13

1. Keratocytes could directly degrade type I collagen and create stromal spaces, promoting corneal neovascularization through VEGFc/VEGFr3-induced MMP13 expression.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MMP-13 antibody

Reference Product	PubMed Publications
Mmp9 antibody	>158 publications with MMP-13 and Mmp9
Timp1 antibody	>57 publications with MMP-13 and Timp1
Mmp14 antibody	>54 publications with MMP-13 and Mmp14
Timp2 antibody	>27 publications with MMP-13 and Timp2
Mmp11 antibody	>16 publications with MMP-13 and Mmp11
Ctsk antibody	>9 publications with MMP-13 and Ctsk
Ctsl1 antibody	>3 publications with MMP-13 and Ctsl1
Col18a1 antibody	>2 publications with MMP-13 and Col18a1
Col9a2 antibody	>1 publications with MMP-13 and Col9a2

Organs/Tissues associated with anti-MMP-13 antibody

Organ/Tissue Name	Pubmed Publications
Connective Tissue Antibodies	>184 publications with MMP-13 and Connective Tissue
Brain Antibodies	>23 publications with MMP-13 and Brain