PLC gamma 2 Antibody – Rabbit Polyclonal

The protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to 1D-myo-inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) using calcium as a cofactor. IP3 and DAG are second messenger molecules important for transmitting signals from growth factor receptors and immune system receptors across the cell membrane. Mutations in this gene have been found in autoinflammation, antibody deficiency, and immune dysregulation syndrome and familial cold autoinflammatory syndrome 3. [provided by RefSeq, Mar 2014]

PLCG2: a calcium dependent phosphatidylinositol-specific phospholipase C. The activated enzyme produces the second messenger molecules diacylglycerol and inositol 1,4,5-trisphosphate. It is a crucial enzyme in transmembrane signaling. Phosphorylated and activated by tyrosine kinases in response to signaling through a variety of growth factor receptors and immune system receptors.

Protein type: Phospholipase; Motility/polarity/chemotaxis; EC 3.1.4.11; Carbohydrate Metabolism - inositol phosphate

Chromosomal Location of Human Ortholog: 16q24.1

Cellular Component: plasma membrane; cytosol

Molecular Function: signal transducer activity; protein binding; phospholipase C activity; phosphoinositide phospholipase C activity

Biological Process: platelet activation; Wnt receptor signaling pathway; inositol phosphate metabolic process; phospholipid catabolic process; calcium-mediated signaling; response to lipopolysaccharide; T cell receptor signaling pathway; activation of store-operated calcium channel activity; B cell receptor signaling pathway; inositol trisphosphate biosynthetic process; regulation of gene expression; B cell differentiation; release of sequestered calcium ion into cytosol; phosphatidylinositol biosynthetic process; negative regulation of programmed cell death; innate immune response; follicular B cell differentiation; blood coagulation

Disease: Autoinflammation, Antibody Deficiency, And Immune Dysregulation, Plcg2-associated; Familial Cold Autoinflammatory Syndrome 3