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LY2886721

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS841964

Background: Cell-permeable. A potent and selective beta-secretase (BACE-1) inhibitor (IC?? = 20 nM for recombinant hBACE1). Does not inhibit other aspartyl proteases such as cathepsin D, pepsin, and renin. A potential agent to treat Alzheimer's Disease. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
LY2886721, Biochemical
Full Product Name
LY2886721
Product Gene Name
LY2886721 biochemical
Product Synonym Names
N-(3-((4aS,7aS)-2-amino-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-7a-yl)-4-fluorophenyl)-5-fluoropicolinamide
Form/Format
Appearance: White solid
Purity/Purification
>=98% by HPLC
Preparation and Storage
At -20 degree C
Shelf Life: 36 months
Molecular Weight
390.41
CAS Number
1262036-50-9
Structure Available?
Yes
Salt Form
No
Cell-Permeable?
Yes
PubChem CID
49837968
Solubility/Reconstitution Instructions
DMSO (~10 mg/ml) or Ethanol (<1 mg/ml)
SMILES
C1C2CSC(=NC2(CO1)C3=C(C=CC(=C3)NC(=O)C4=NC=C(C=C4)F)F)N
InChi
InChI=1S/C18H16F2N4O2S/c19-11-1-4-15(22-6-11)16(25)23-12-2-3-14(20)13(5-12)18-9-26-7-10(18)8-27-17(21)24-18/h1-6,10H,7-9H2,(H2,21,24)(H,23,25)/t10-,18-/m0/s1
InChi Key
NIDRNVHMMDAAIK-YPMLDQLKSA-N
Handling
Protect from air and light

Product Categories/Family for LY2886721 biochemical

Enzyme Inhibitors; Secretase Inhibitors and Biochemicals; Enzyme Inhibitors; Secretase Inhibitors and Biochemicals; Biochemicals (A-Z)

Structure of LY2886721 biochemical

LY2886721 Biochemical – Cat# MBS841964

Other Notes

Small volumes of LY2886721 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for LY2886721 purchase

MBS841964 is a biochemical targeting LY2886721.
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