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GSK429286A

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS841972

Background: GSK429286A is a potent and selective Rho-Kinase (ROCK) inhibitor (IC?? = 14 and 63 nM for ROCK1 and ROCK2, respectively). ROCK inhibitors have been found to prevent apoptosis, as well as enhance the survival and cloning efficiency of dissociated… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
GSK429286A, Biochemical
Full Product Name
GSK429286A
Product Synonym Names
4-[4-(Trifluoromethyl)phenyl]-N-(6-Fluoro-1H-indazol-5-yl)-2-methyl-6-oxo-1,4,5,6-tetrahydro-3-pyridinecarboxamide; GSK429286
Form/Format
Appearance: White solid
Purity/Purification
>98% by HPLC
Preparation and Storage
At -20 degree C
Shelf Life: 36 months
Molecular Weight
432.27
CAS Number
864082-47-3
Structure Available?
Y
Salt Form
No
Cell-Permeable?
Yes
MDL Number
MFCD16618404
PubChem CID
11373846
Solubility/Reconstitution Instructions
DMSO (~40 mg/ml) or EtOH (~10 mg/ml)
SMILES
CC1=C(C(CC(=O)N1)C2=CC=C(C=C2)C(F)(F)F)C(=O)NC3=C(C=C4C(=C3)C=NN4)F
InChi
nChI=1S/C21H16F4N4O2/c1-10-19(20(31)28-17-6-12-9-26-29-16(12)8-15(17)22)14(7-18(30)27-10)11-2-4-13(5-3-11)21(23,24)25/h2-6,8-9,14H,7H2,1H3,(H,26,29)(H,27,30)(H,28,31)
InChi Key
OLIIUAHHAZEXEX-UHFFFAOYSA-N
Handling
Protect from air and light

Product Categories/Family for GSK429286A biochemical

Enzyme Inhibitors; Protein Kinase Inhibitors; Rho Kinase (ROCK) InhibitorsBiochemicals; Enzyme Inhibitors; Protein Kinase Inhibitors; Rho Kinase (ROCK) InhibitorsStem Cell Research Tools; Stem Cell Fate Regulators; Self-Renewal and SurvivalStem Cell Resea

Structure of GSK429286A biochemical

GSK429286A Biochemical – Cat# MBS841972

Other Notes

Small volumes of GSK429286A biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GSK429286A purchase

MBS841972 is a biochemical targeting GSK429286A.
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