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Regorafenib

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS841984

Background: Regorafenib is a multi-kinase inhibitor targeting angiogenic (VEGFR, TIE-2), stromal (PDGFR-beta) and oncogenic (RAF, RET and c-KIT) receptor tyrosine kinases, with IC??s of 17, 40 and 69 nM for c-KIT, VEGFR2, B-Raf, respectively. Displays… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
Regorafenib, Biochemical
Full Product Name
Regorafenib
Product Synonym Names
4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)-N-methylpicolinamide; BAY 73-4506
Form/Format
Appearance: Off-white solid
Purity/Purification
>=98% by HPLC
Preparation and Storage
At -20 degree C
Shelf Life: 36 months
Molecular Weight
482.81
CAS Number
755037-03-7
Structure Available?
Yes
Salt Form
No
Cell-Permeable?
yes
PubChem CID
11167602
Solubility/Reconstitution Instructions
DMSO (>50 mg/ml)
SMILES
CNC(=O)C1=NC=CC(=C1)OC2=CC(=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F)F
InChi
InChI=1S/C21H15ClF4N4O3/c1-27-19(31)18-10-13(6-7-28-18)33-12-3-5-17(16(23)9-12)30-20(32)29-11-2-4-15(22)14(8-11)21(24,25)26/h2-10H,1H3,(H,27,31)(H2,29,30,32)
InChi Key
FNHKPVJBJVTLMP-UHFFFAOYSA-N
Handling
Protect from air and light

Product Categories/Family for Regorafenib biochemical

Enzyme Inhibitors; Protein Kinase Inhibitors; Protein Tyrosine Kinase InhibitorsEnzyme Inhibitors; Enzyme Inhibitors (A-Z) Biochemicals; Enzyme Inhibitors; Protein Kinase Inhibitors; Protein Tyrosine Kinase InhibitorsBiochemicals; Enzyme Inhibitors; Enzym

Structure of Regorafenib biochemical

Regorafenib Biochemical – Cat# MBS841984

Other Notes

Small volumes of Regorafenib biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Regorafenib purchase

MBS841984 is a biochemical targeting Regorafenib.
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