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Ruxolitinib, Free base

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS841997

Background: Ruxolitinib is a potent and selective Janus kinase (JAK) inhibitor with with IC??'s of 2.7 and 4.5 nM for JAK1 and JAK2, respectively. Displays clinically significant activity in myelofibrosis. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
Ruxolitinib, Biochemical
Full Product Name
Ruxolitinib, Free base
Product Synonym Names
INCB018424; INC18424; NCB018424; NCB18424
Form/Format
Appearance: Off-white solid
Purity/Purification
>=99% by HPLC
Preparation and Storage
At -20 degree C
Shelf Life: 24 months
Molecular Weight
306.37
CAS Number
941678-49-5
Structure Available?
Yes
Cell-Permeable?
Yes
MDL Number
MFCD12031592
PubChem CID
25126798
Solubility/Reconstitution Instructions
DMSO (25 mg/ml) or EtOH (~ 15 mg/ml)
SMILES
C1CCC(C1)C(CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC=N3
InChi
InChI=1S/C17H18N6/c18-7-5-15(12-3-1-2-4-12)23-10-13(9-22-23)16-14-6-8-19-17(14)21-11-20-16/h6,8-12,15H,1-5H2,(H,19,20,21)/t15-/m1/s1
InChi Key
HFNKQEVNSGCOJV-OAHLLOKOSA-N
Handling
Protect from air and light

Product Categories/Family for Ruxolitinib biochemical

Enzyme Inhibitors; Protein Kinase Inhibitors; JAK Inhibitors and Biochemicals; Enzyme Inhibitors; Protein Kinase Inhibitors; JAK Inhibitors; Signaling Pathways; JAK/Stat Signaling; JAK Inhibitors and Biochemicals (A-z)

Structure of Ruxolitinib biochemical

Ruxolitinib, Free base Biochemical – Cat# MBS841997

Other Notes

Small volumes of Ruxolitinib biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Ruxolitinib purchase

MBS841997 is a biochemical targeting Ruxolitinib. Also known as Ruxolitinib, Free base.
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