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Nilotinib

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS842031

Background: A potent, selective BCR-ABL inhibitor that fits into the ATP-binding site of the BCR-ABL protein with higher affinity than imatinib.   Nilotinib is not only more potent than imatinib against wild-type BCR-ABL (IC?? < 30 nM), but also… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
Nilotinib, Biochemical
Full Product Name
Nilotinib
Product Synonym Names
4-Methyl-N-[3-(4-methyl-1H-imidazol-1-yl)- 5-(trifluoromethyl)phenyl]-3- [(4-pyridin-3-ylpyrimidin-2-yl) amino]benzamide
Form/Format
Appearance: Off-white solid
Purity/Purification
>=98% by HPLC
Preparation and Storage
At -20 degree C
Shelf Life: 24 months
Molecular Weight
529.52
CAS Number
641571-10-0
Structure Available?
Yes
Salt Form
No
Cell-Permeable?
Yes
MDL Number
MFCD09833716
PubChem CID
644241
Solubility/Reconstitution Instructions
DMSO (50 mg/ml)
SMILES
CC1=C(C=C(C=C1)C(=O)NC2=CC(=CC(=C2)N3C=C(N=C3)C)C(F)(F)F)NC4=NC=CC(=N4)C5=CN=CC=C5
InChi
InChI=1S/C28H22F3N7O/c1-17-5-6-19(10-25(17)37-27-33-9-7-24(36-27)20-4-3-8-32-14-20)26(39)35-22-11-21(28(29,30)31)12-23(13-22)38-15-18(2)34-16-38/h3-16H,1-2H3,(H,35,39)(H,33,36,37)
InChi Key
HHZIURLSWUIHRB-UHFFFAOYSA-N
Handling
Protect from air and moisture

Product Categories/Family for Nilotinib biochemical

Biochemicals; Enzyme Inhibitors; Protein Kinase Inhibitors; Protein Tyrosine Kinase Inhibitors and; Biochemicals; Biochemicals (A-Z)

Structure of Nilotinib biochemical

Nilotinib Biochemical – Cat# MBS842031

Other Notes

Small volumes of Nilotinib biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Nilotinib purchase

MBS842031 is a biochemical targeting Nilotinib.
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