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GSK-2126458

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS842084

Background: Cell-permeable. A highly potent, pan phosphoinositide 3-kinase (PI 3-K) family kinase inhibitor with biochemical Ki's of 0.019 nM (PI 3-K?), 0.13 nM (PI 3-Kbeta), 0.024 nM (PI 3-Kdelta), 0.06 nM (PI 3-K?), 0.18 nM (mTORC1), and 0.3 nM (mTORC2). In… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
GSK-2126458, Biochemical
Full Product Name
GSK-2126458
Product Gene Name
GSK-2126458 biochemical
Product Synonym Names
2,4-Difluoro-N-{2-(methyloxy)-5-[4-(4-pyridazinyl)-6-quinolinyl]-3-pyridinyl}benzenesulfonamide
Form/Format
Appearance: Off-white solid
Purity/Purification
>=98% by HPLC
Preparation and Storage
At -20 degree C
Shelf Life: 48 months
Molecular Weight
505.5
CAS Number
1086062-66-9
Structure Available?
Yes
Salt Form
No
Cell-Permeable?
Yes
MDL Number
MFCD16038929
PubChem CID
25167777
Solubility/Reconstitution Instructions
DMSO (~ 5 mg/ml)
SMILES
COC1=C(C=C(C=N1)C2=CC3=C(C=CN=C3C=C2)C4=CN=NC=C4)NS(=O)(=O)C5=C(C=C(C=C5)F)F
InChi
InChI=1S/C25H17F2N5O3S/c1-35-25-23(32-36(33,34)24-5-3-18(26)12-21(24)27)11-17(13-29-25)15-2-4-22-20(10-15)19(7-8-28-22)16-6-9-30-31-14-16/h2-14,32H,1H3
InChi Key
CGBJSGAELGCMKE-UHFFFAOYSA-N
Handling
Protect from light and air

Product Categories/Family for GSK-2126458 biochemical

Biochemicals; Enzyme Inhibitors; Protein Kinase Inhibitors; PI 3-Kinase Inhibitors and Biochemicals; Enzyme Inhibitors; Protein Kinase Inhibitors; mTOR Inhibitors and Biochemicals (A-Z)

Structure of GSK-2126458 biochemical

GSK-2126458 Biochemical – Cat# MBS842084

Other Notes

Small volumes of GSK-2126458 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GSK-2126458 purchase

MBS842084 is a biochemical targeting GSK-2126458.
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