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GSK343

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS842173

Background: A potent histone H3-lysine 27 (H3K27) methyltransferase EZH2 inhibitor (IC?? = 4 nM). Diplays 1000-fold selectivity for other HMTs except EZH1 (60-fold selectivity). GSK343 inhibits H3K27 methylation in HCC1806 cells with an IC?? of More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
GSK343, Biochemical
Full Product Name
GSK343
Product Gene Name
GSK343 biochemical
Product Synonym Names
1-Isopropyl-N-((6-methyl-2-oxo-4-propyl-1,2-dihydropyridin-3-yl)methyl)-6-(2-(4-methylpiperazin-1-yl)pyridine-4-yl)-1H-indazole-4-carboxamide
Form/Format
Appearance: Crystalline solid
Purity/Purification
>=99% by HPLC
Preparation and Storage
At -20 degree C
Shelf Life: 36 months
Molecular Weight
541.69
Structure Available?
Yes
Salt Form
No
Cell-Permeable?
Yes
PubChem CID
71268957
Solubility/Reconstitution Instructions
DMSO
SMILES
CCCC1=C(CNC(=O)C2=C3C=NN(C(C)C)C3=CC(=C2)C2=CC=NC(=C2)N2CCN(C)CC2)C(=O)NC(C)=C1
InChi
InChI=1S/C31H39N7O2/c1-6-7-23-14-21(4)35-31(40)26(23)18-33-30(39)25-15-24(16-28-27(25)19-34-38(28)20(2)3)22-8-9-32-29(17-22)37-12-10-36(5)11-13-37/h8-9,14-17,19-20H,6-7,10-13,18H2,1-5H3,(H,33,39)(H,35,40)
InChi Key
ULNXAWLQFZMIHX-UHFFFAOYSA-N
Handling
Protect from light and moisture

Product Categories/Family for GSK343 biochemical

Enzyme Inhibitors; Methyltransferase Inhibitors and Biochemicals; Enzyme Inhibitors; Methyltransferase Inhibitors and Biochemicals (A-Z)

Structure of GSK343 biochemical

GSK343 Biochemical – Cat# MBS842173

Other Notes

Small volumes of GSK343 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GSK343 purchase

MBS842173 is a biochemical targeting GSK343.
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