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GSK-J1 (Free acid)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS842198

Background: GSK-J1 is a potent and selective inhibitor of jumonji H3K27 histone demethylases JMJD3 and UTX (IC?? = 60 nM, human JMJD3). This is the first known inhibitor selective for the H3K27me3-specific JMJ subfamily which binds to the active catalytic… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
GSK-J1, Biochemical
Full Product Name
GSK-J1 (Free acid)
Product Gene Name
GSK-J1 biochemical
Product Synonym Names
N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-beta-alanine
Form/Format
Appearance: Pale yellow solid
Purity/Purification
>=98% by TLC
Preparation and Storage
At -20 degree C
Shelf Life: 36 months
Molecular Weight
398.45
CAS Number
1373422-53-7
Structure Available?
Y
Salt Form
No
Cell-Permeable?
Y
MDL Number
MFCD22683851
PubChem CID
56963315 
Solubility/Reconstitution Instructions
DMSO (~ 20 mg/ml)
SMILES
C1CN(CCC2=CC=CC=C21)C3=CC(=NC(=N3)C4=CC=CC=N4)NCCC(=O)O
InChi
 InChI=1S/C22H23N5O2/c28-21(29)8-12-24-19-15-20(26-22(25-19)18-7-3-4-11-23-18)27-13-9-16-5-1-2-6-17(16)10-14-27/h1-7,11,15H,8-10,12-14H2,(H,28,29)(H,24,25,26)
InChi Key
AVZCPICCWKMZDT-UHFFFAOYSA-N
Handling
Protect from light and moisture

Product Categories/Family for GSK-J1 biochemical

Enzyme Inhibitors; Histone Demethylase (HDM) InhibitorsBiochemicals; Enzyme Inhibitors; Histone Demethylase (HDM) InhibitorsEpigenetics; Eraser Enzymes; Histone Demethylases (HDMs); HDM InhibitorsEpigenetics; Epigenetic Modulators (A-Z) Biochemicals; Bioc

Structure of GSK-J1 biochemical

GSK-J1 (Free acid) Biochemical – Cat# MBS842198

Other Notes

Small volumes of GSK-J1 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GSK-J1 purchase

MBS842198 is a biochemical targeting GSK-J1. Also known as GSK-J1 (Free acid).
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