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DBZ

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS842262

Background: DBZ is a potent gamma-secretase inhibitor that blocks the cleavage of Notch into its active signaling effector, Notch intracellular domain, in human T cell lymphoma (SupT1) cells (IC?? = 1.7 nM). More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
DBZ, Biochemical
Full Product Name
DBZ
Product Gene Name
DBZ biochemical
Product Synonym Names
N-[(1S)-2-[[(7S)-6,7-dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluoro-benzeneacetamide
Form/Format
Appearance: White to off-white solid
Purity/Purification
>=98% by HPLC
Preparation and Storage
At -20 degree C
Shelf Life: 48 months
Molecular Weight
463.48
CAS Number
209984-56-5
Structure Available?
Yes
Salt Form
No
Cell-Permeable?
Yes
PubChem CID
11454028
Solubility/Reconstitution Instructions
DMSO (~ 35 mg/ml)
SMILES
CC(C(=O)NC1C2=CC=CC=C2C3=CC=CC=C3N(C1=O)C)NC(=O)CC4=CC(=CC(=C4)F)F
InChi
 InChI=1S/C26H23F2N3O3/c1-15(29-23(32)13-16-11-17(27)14-18(28)12-16)25(33)30-24-21-9-4-3-7-19(21)20-8-5-6-10-22(20)31(2)26(24)34/h3-12,14-15,24H,13H2,1-2H3,(H,29,32)(H,30,33)/t15-,24-/m0/s1
InChi Key
QSHGISMANBKLQL-OWJWWREXSA-N
Handling
Protect from air and light

Product Categories/Family for DBZ biochemical

Enzyme Inhibitors; Secretase InhibitorsBiochemicals; Enzyme Inhibitors; Secretase InhibitorsBiochemicals; Biochemicals (A-Z)

Structure of DBZ biochemical

DBZ Biochemical – Cat# MBS842262

Other Notes

Small volumes of DBZ biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DBZ purchase

MBS842262 is a biochemical targeting DBZ.
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