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LGK974

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS842300

Background: LGK-974 is a potent and specific inhibitor of Porcupine (porcn), a Wnt-specific acyltransferase (IC?? = ~0.4 nM). GK974 potently inhibits Wnt signaling, has strong efficacy in rodent tumor models, and is well-tolerated. In addition, head and neck… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
LGK974, Biochemical
Full Product Name
LGK974
Product Gene Name
LGK974 biochemical
Product Synonym Names
2-(2',3-dimethyl-[2,4'-bipyridin]-5-yl)-N-(5-(pyrazin-2-yl)pyridin-2-yl)acetamide
Form/Format
Appearance: Crystalline solid
Purity/Purification
>=98% by HPLC
Preparation and Storage
At -20 degree C
Shelf Life: 48 months
Molecular Weight
396.44
CAS Number
1243244-14-5
Structure Available?
Yes
Salt Form
No
Cell-Permeable?
Yes
PubChem CID
46926973
Solubility/Reconstitution Instructions
DMSO (~ 35 mg/ml)
SMILES
CC1=C(N=CC(=C1)CC(=O)NC2=NC=C(C=C2)C3=NC=CN=C3)C4=CC(=NC=C4)C
InChi
InChI=1S/C23H20N6O/c1-15-9-17(12-28-23(15)18-5-6-25-16(2)10-18)11-22(30)29-21-4-3-19(13-27-21)20-14-24-7-8-26-20/h3-10,12-14H,11H2,1-2H3,(H,27,29,30)
InChi Key
XXYGTCZJJLTAGH-UHFFFAOYSA-N
Handling
Protect from air and light

Product Categories/Family for LGK974 biochemical

Enzyme Inhibitors; Wnt Signaling InhibitorsBiochemicals; Enzyme Inhibitors; Wnt Signaling InhibitorsDiabetes; Obesity & Metabolic Syndrome; Signaling Pathways in Diabetes and Obesity; GSK-3/Wnt Signaling; Wnt/b-Catenin Signaling Pathway ModulatorsSignalin

Structure of LGK974 biochemical

LGK974 Biochemical – Cat# MBS842300

Other Notes

Small volumes of LGK974 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for LGK974 purchase

MBS842300 is a biochemical targeting LGK974.
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