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Necrostatin-5

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS842352

Background: Inhibits non-apoptotic cell death pathway by inhibition of the death domain receptor-associated adaptor kinase RIP1. Three distinct mechanisms appear to be involved in necroptosis, the alternative active cell death pathway: T-loop dependent… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
Necrostatin-5, Biochemical
Full Product Name
Necrostatin-5
Product Synonym Names
3-p-Methoxyphenyl-5,6-tetramethylenothieno[2,3-d]pyrimidin-4-one-2-mercaptoethylcyanide; Nec-5
Form/Format
Appearance: White to off-white solid
Purity/Purification
>=98% by NMR
Preparation and Storage
At -20 degree C
Shelf Life: 24 months
Molecular Weight
383.49
CAS Number
337349-54-9
Structure Available?
Yes
Salt Form
No
Cell-Permeable?
Yes
MDL Number
MFCD01448275
PubChem CID
1913406
Solubility/Reconstitution Instructions
DMSO (~10 mg/ml)
SMILES
COC1=CC=C(C=C1)N2C(=O)C3=C(N=C2SCC#N)SC4=C3CCCC4
InChi
InChI=1S/C19H17N3O2S2/c1-24-13-8-6-12(7-9-13)22-18(23)16-14-4-2-3-5-15(14)26-17(16)21-19(22)25-11-10-20/h6-9H,2-5,11H2,1H3
InChi Key
VGONMECBFMCKBS-UHFFFAOYSA-N
Handling
Protect from air and light

Product Categories/Family for Necrostatin-5 biochemical

Apoptosis; Necroptosis Inhibitors and Biochemicals (A-Z)

Structure of Necrostatin-5 biochemical

Necrostatin-5 Biochemical – Cat# MBS842352

Other Notes

Small volumes of Necrostatin-5 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Necrostatin-5 purchase

MBS842352 is a biochemical targeting Necrostatin-5.
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