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SIRT1 Inhibitor, EX-527 (EX-527)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS842382

Background: A potent SIRT1 inhibitor (IC?? = 38 nM). EX-527 is 200-500-fold more selective for SIRT1 than for SIRT2 or SIRT3. Does not inhibit SIRT4-7, does not inhibit class I/II HDAC activity at concentrations up to 100uM. Enhances p53 acetylation in… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
SIRT1 Inhibitor, EX-527, Biochemical
Full Product Name
SIRT1 Inhibitor, EX-527
Product Synonym Names
EX-527; 6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide
Form/Format
Appearance: White solid
Purity/Purification
>=97% by HPLC
Preparation and Storage
4 degree C
Shelf Life: 24 months
Molecular Weight
248.71
CAS Number
49843-98-3
Structure Available?
Yes
Salt Form
No
Cell-Permeable?
Yes
MDL Number
MFCD03009471
PubChem CID
5113032
Solubility/Reconstitution Instructions
DMSO (20 mg/ml)
SMILES
C1CC(C2=C(C1)C3=C(N2)C=CC(=C3)Cl)C(=O)N
InChi
InChI=1S/C13H13ClN2O/c14-7-4-5-11-10(6-7)8-2-1-3-9(13(15)17)12(8)16-11/h4-6,9,16H,1-3H2,(H2,15,17)
InChi Key
FUZYTVDVLBBXDL-UHFFFAOYSA-N
Handling
Protect from air and light

Structure of SIRT1 Inhibitor, EX-527 biochemical

SIRT1 Inhibitor, EX-527 Biochemical – Cat# MBS842382

Other Notes

Small volumes of SIRT1 Inhibitor, EX-527 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

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MBS842382 is a biochemical targeting SIRT1 Inhibitor, EX-527.
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