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PND-1186

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS842411

Background: PND-1186 is a potent FAK (Focal adhesion kinase) inhibitor (IC?? = 1.5 nM) with potential antineoplastic activity. PND-1186 inhibits FAK, blocks fibronectin-stimulated FAK autophosphorylation of Tyr397, and may prevent the integrin-mediated… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
PND-1186, Biochemical
Full Product Name
PND-1186
Product Gene Name
PND-1186 biochemical
Product Synonym Names
2-((2-((2-methoxy-4-morpholinophenyl)amino)-5-(trifluoromethyl)pyridin-4-yl)amino)-N-methylbenzamide; VS-4718; SR-2516;PND 1186;PND1186;SR 2516;SR2516
Form/Format
Appearance: White to off-white solid
Purity/Purification
>=98% by HPLC
Preparation and Storage
At -20 degree C
Shelf Life: 36 months
Molecular Weight
501.5
CAS Number
1061353-68-1
Structure Available?
Yes
Salt Form
No
Cell-Permeable?
yes
PubChem CID
25073775
Solubility/Reconstitution Instructions
DMSO
SMILES
CNC(=O)C1=CC=CC=C1NC2=CC(=NC=C2C(F)(F)F)NC3=C(C=C(C=C3)N4CCOCC4)OC
InChi
InChI=1S/C25H26F3N5O3/c1-29-24(34)17-5-3-4-6-19(17)31-21-14-23(30-15-18(21)25(26,27)28)32-20-8-7-16(13-22(20)35-2)33-9-11-36-12-10-33/h3-8,13-15H,9-12H2,1-2H3,(H,29,34)(H2,30,31,32)
InChi Key
IGUBBWJDMLCRIK-UHFFFAOYSA-N
Handling
Protect from air and light

Product Categories/Family for PND-1186 biochemical

Enzyme Inhibitors; Protein Kinase Inhibitors; Protein Tyrosine Kinase InhibitorsEnzyme Inhibitors; Enzyme Inhibitors (A-Z) Biochemicals; Enzyme Inhibitors; Protein Kinase Inhibitors; Protein Tyrosine Kinase InhibitorsBiochemicals; Enzyme Inhibitors; Enzym

Structure of PND-1186 biochemical

PND-1186 Biochemical – Cat# MBS842411

Other Notes

Small volumes of PND-1186 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PND-1186 purchase

MBS842411 is a biochemical targeting PND-1186.
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