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GW-5074

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS842447

Background: Cell-permeable. A potent inhibitor of cRAF1 kinase (IC?? = 9 nM). Displays 100-fold selectivity for cRAF1 over CDK1, CDK2, c-src, ERK2, MEK, p38, Tie2, VEGFR2 and c-fm. Displays neuroprotective effects in vivo via a mechanism that is independent… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
GW-5074, Biochemical
Full Product Name
GW-5074
Product Gene Name
GW-5074 biochemical
Product Synonym Names
3-(3,5-Dibromo-4-hydroxybenzylidene)-5-iodo-1,3-dihydroindol-2-one
Form/Format
Appearance: Dark orange solid
Purity/Purification
>=98% by TLC
Preparation and Storage
At -20 degree C
Shelf Life: 36 months
Molecular Weight
520.95
CAS Number
220904-83-6
Structure Available?
Yes
Salt Form
No
Cell-Permeable?
Yes
MDL Number
MFCD03453076
PubChem CID
5924208
Solubility/Reconstitution Instructions
DMSO (~50 mg/ml)
SMILES
C1=CC2=C(C=C1I)C(=CC3=CC(=C(C(=C3)Br)O)Br)C(=O)N2
InChi
InChI=1S/C15H8Br2INO2/c16-11-4-7(5-12(17)14(11)20)3-10-9-6-8(18)1-2-13(9)19-15(10)21/h1-6,20H,(H,19,21)/b10-3-
InChi Key
LMXYVLFTZRPNRV-KMKOMSMNSA-N
Handling
Protect from light and air

Product Categories/Family for GW-5074 biochemical

Enzyme Inhibitors; Protein Kinase Inhibitors; Raf Kinase Inhibitors and Biochemicals; Enzyme Inhibitors; Protein Kinase Inhibitors; Raf Kinase Inhibitors and Signaling Pathways; MAP Kinase Pathway; MAP Kinase/MEK Inhibitors and Biochemicals; Biochemicals

Structure of GW-5074 biochemical

GW-5074 Biochemical – Cat# MBS842447

Other Notes

Small volumes of GW-5074 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GW-5074 purchase

MBS842447 is a biochemical targeting GW-5074.
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