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TAPI-1

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS842463

Background: Inhibitor of TNF-alpha processing (IC?? = 100 nM), similar to TAPI-0, but more stable in tissue culture and in vivo. Inhibits TACE and other metalloproteases. Blocks release of TNF- alpha (IC?? = 50-100 muM), APP (1-8 muM), IL6R (5- 10 muM), TNFRI… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
TAPI-1, Biochemical
Full Product Name
TAPI-1
Product Gene Name
TAPI-1 biochemical
Product Synonym Names
N-(R)-(2-(Hydroxyaminocarbonyl)methyl)-4-methylpentanoyl-L-naphthylalanyl-L-alanine amide; TNF protease inhibitor-0; C1
Form/Format
Appearance: White solid
Purity/Purification
>=95% by HPLC
Preparation and Storage
At -20 degree C
Shelf Life: 24 months
Molecular Weight
499.3
CAS Number
171235-71-5
Structure Available?
Yes
Cell-Permeable?
No
PubChem CID
9827273
Solubility/Reconstitution Instructions
DMSO and MEOH
SMILES
CC(C)CC(CC(=O)NO)C(=O)NC(CC1=CC2=CC=CC=C2C=C1)C(=O)NC(C)C(=O)NCCN
InChi
InChI=1S/C26H37N5O5/c1-16(2)12-21(15-23(32)31-36)25(34)30-22(26(35)29-17(3)24(33)28-11-10-27)14-18-8-9-19-6-4-5-7-20(19)13-18/h4-9,13,16-17,21-22,36H,10-12,14-15,27H2,1-3H3,(H,28,33)(H,29,35)(H,30,34)(H,31,32)/t17-,21?,22-/m0/s1
InChi Key
AWNBSWDIOCXWJW-OWHMDLSXSA-N
Handling
Protect from air and moisture

Product Categories/Family for TAPI-1 biochemical

Biochemicals; Enzyme Inhibitors; Matrix Metalloproteinase (MMP) Inhibitors and Biochemicals (A-Z)

Structure of TAPI-1 biochemical

TAPI-1 Biochemical – Cat# MBS842463

Other Notes

Small volumes of TAPI-1 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TAPI-1 purchase

MBS842463 is a biochemical targeting TAPI-1.
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