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SGC0946

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS842516

Background: A potent and selective DOT1L inhibitor (IC?? = 0. 3 nM in a radioactive enzyme assay); >100-fold selective for other histone methyltransferases (HMTs). SGC0946 also potently reduces H3K79 dimethylation with cellular IC?? of 2.6 nM in A431 cells,… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
SGC0946, Biochemical
Full Product Name
SGC0946
Product Gene Name
SGC0946 biochemical
Product Synonym Names
1-[3-[[[(2R,3S,4R,5R)-5-(4-Amino-5-bromo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl](isopropyl)amino]propyl]-3-[4-(2,2-dimethylethyl)phenyl]urea
Form/Format
Appearance: White solid
Purity/Purification
>=98% by HPLC
Preparation and Storage
At -20 degree C
Shelf Life: 24 months
Molecular Weight
618.57
Structure Available?
Yes
Salt Form
No
Cell-Permeable?
Yes
PubChem CID
71729976
Solubility/Reconstitution Instructions
DMSO (> 50 mg/ml) or EtOH (>50 mg/ml)
SMILES
CC(C)N(CCCNC(=O)NC1=CC=C(C=C1)C(C)(C)C)CC2C(C(C(O2)N3C(=CC4=C3N=CN=C4N)Br)O)O
InChi
InChI=1S/C28H40BrN7O4/c1-16(2)35(12-6-11-31-27(39)34-18-9-7-17(8-10-18)28(3,4)5)14-20-22(37)23(38)26(40-20)36-21(29)13-19-24(30)32-15-33-25(19)36/h7-10,13,15-16,20,22-23,26,37-38H,6,11-12,14H2,1-5H3,(H2,30,32,33)(H2,31,34,39)/t20-,22-,23-,26-/m1/s1
InChi Key
CNTIACSNJOOHEX-HUBRGWSESA-N
Handling
Protect from air and light

Product Categories/Family for SGC0946 biochemical

Enzyme Inhibitors; Methyltransferase Inhibitors and Biochemicals; Enzyme Inhibitors; Methyltransferase Inhibitors and Epigenetics; Writer Enzymes; Protein Lysine Methyltransferases (PKMTs); PKMT Inhibitors and Biochemicals; Biochemicals (A-Z)

Structure of SGC0946 biochemical

SGC0946 Biochemical – Cat# MBS842516

Other Notes

Small volumes of SGC0946 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SGC0946 purchase

MBS842516 is a biochemical targeting SGC0946.
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