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MK-1775

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS842524

Background: MK-1775 is a potent and selective inhibitor of the tyrosine kinase WEE1 (IC?? = 5.2 nM). It selectively targets and inhibits WEE1, a tyrosine kinase that phosphorylates cyclin-dependent kinase 1 (CDC2) to inactivate the CDC2/cyclin B complex.… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
MK-1775, Biochemical
Full Product Name
MK-1775
Product Gene Name
MK-1775 biochemical
Product Synonym Names
2-allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-6-(4-(4-methylpiperazin-1-yl)phenylamino)-1,2-dihydropyrazolo[3,4-d]pyrimidin-3-one
Form/Format
Appearance: Crystalline solid
Purity/Purification
>=98% by HPLC
Preparation and Storage
At -20 degree C
Shelf Life: 36 months
Molecular Weight
500.6
CAS Number
955365-80-7
Structure Available?
Yes
Salt Form
No
Cell-Permeable?
Yes
PubChem CID
24856436
Solubility/Reconstitution Instructions
DMSO (~80 mg/ml)
SMILES
CC(C)(C1=NC(=CC=C1)N2C3=NC(=NC=C3C(=O)N2CC=C)NC4=CC=C(C=C4)N5CCN(CC5)C)O
InChi
InChI=1S/C27H32N8O2/c1-5-13-34-25(36)21-18-28-26(29-19-9-11-20(12-10-19)33-16-14-32(4)15-17-33)31-24(21)35(34)23-8-6-7-22(30-23)27(2,3)37/h5-12,33-16-14-32(4)15-17-33)31-24(21)35(34)23-8-6-7-22(30-23)27(2,3)37/h5-12,
InChi Key
BKWJAKQVGHWELA-UHFFFAOYSA-N
Handling
Protect from light and moisture

Product Categories/Family for MK-1775 biochemical

Enzyme Inhibitors; Protein Kinase Inhibitors; Protein Tyrosine Kinase Inhibitors and Biochemicals; Enzyme Inhibitors; Protein Kinase Inhibitors; Protein Tyrosine Kinase Inhibitors and Biochemicals; Biochemicals (A-Z)

Structure of MK-1775 biochemical

MK-1775 Biochemical – Cat# MBS842524

Other Notes

Small volumes of MK-1775 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MK-1775 purchase

MBS842524 is a biochemical targeting MK-1775.
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