LY294002

LY294002 is a morpholine-containing potent reversible inhibitor of phosphoinositide 3-kinases (PI3Ks) and BETproteins. It is reported to be promote the differentiation of insulin-producing cells from embryonic cells and inhibit the growth of ovarian carcinomas.

Gharbi, S., Zvelebil, M., Shuttleworth, S., Hancox, T., Saghir, N., Timms, J., & Waterfield, M. (2007). Exploring the specificity of the PI3K family inhibitor LY294002. Biochem. J, 404, 15-21.
Vlahos, C. J., Matter, W. F., Hui, K. Y., & Brown, R. F. (1994). A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002). Journal of Biological Chemistry, 269(7), 5241-5248.
Sanchezmargalet, V., Goldfine, I. D., Vlahos, C. J., & Sung, C. K. (1994). Role of phosphatidylinositol-3-kinase in insulin receptor signaling: studies with inhibitor, LY294002. Biochemical and biophysical research communications,204(2), 446-452

Small volumes of LY294002 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS696296 is a biochemical targeting LY294002.